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10.1073/pnas.1415751111 http://scihub22266oqcxt.onion/10.1073/pnas.1415751111 C4273333!4273333!25468964     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (50): E5354-62 Nephropedia Template TP {{tp|p=25468964|t=2014. Sodium recognition by the Na+/Ca2+ exchanger in the outward-facing conformation |pdf=|usr=}}{{25468964}} gab.com Text Sodium recognition by the Na+/Ca2+ exchanger in the outward-facing conformation JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25468964 #FOAvip Na+/Ca2+ exchangers (NCXs) have a key role in the homeostasis of cellular Ca2+ and consequently are implicated in diverse human-health disorders, including neurodegenerative and cardiovascular diseases. A detailed understanding of the molecular mechanisms of these membrane proteins is therefore of interest from fundamental and biomedical standpoints. Here, we establish the structural mechanism of Na+ recognition in a prokaryotic NCX homolog, using atomistic molecular-dynamics simulations based on recently reported crystallographic data, as well as experimental transport assays of wild-type and mutagenized exchangers. The results have general implications pertaining to the ion exchange stoichiometry and electrogenicity of the Na+/Ca2+ transport cycle across the NCX family, and provide the basis for future investigations of the conformational mechanism of these important transporters. Twit Text FOAVip Sodium recognition by the Na+/Ca2+ exchanger in the outward-facing conformation ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25468964 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25468964 #FOAvip English Wikipedia <ref>{{Cite pmid|25468964}}</ref> Sodium recognition by the Na+/Ca2+ exchanger in the outward-facing conformation #MMPMID25468964 Marinelli F; Almagor L; Hiller R; Giladi M; Khananshvili D; Faraldo-Gómez JD Proc Natl Acad Sci U S A 2014[Dec]; 111 (50): E5354-62 PMID25468964show ga Na+/Ca2+ exchangers (NCXs) have a key role in the homeostasis of cellular Ca2+ and consequently are implicated in diverse human-health disorders, including neurodegenerative and cardiovascular diseases. A detailed understanding of the molecular mechanisms of these membrane proteins is therefore of interest from fundamental and biomedical standpoints. Here, we establish the structural mechanism of Na+ recognition in a prokaryotic NCX homolog, using atomistic molecular-dynamics simulations based on recently reported crystallographic data, as well as experimental transport assays of wild-type and mutagenized exchangers. The results have general implications pertaining to the ion exchange stoichiometry and electrogenicity of the Na+/Ca2+ transport cycle across the NCX family, and provide the basis for future investigations of the conformational mechanism of these important transporters. äSodium recognition by the Na+/Ca2+ exchanger in the outward-facing con(epmc).pdf DeepDyve Pubget Overpricing