Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.molcel.2014.09.009 http://scihub22266oqcxt.onion/10.1016/j.molcel.2014.09.009 C4272865!4272865 !25306923     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25306923 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2014 ; 56 (2 ): 246-260 Nephropedia Template TP {{tp|p=25306923 |t=2014. Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly |pdf=|usr=}}{{25306923 }} gab.com Text Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25306923 #FOAvip Polyubiquitination by E2 and E3 enzymes is a predominant mechanism regulating protein function. Some RING E3s, including anaphase-promoting complex/cyclosome (APC), catalyze polyubiquitination by sequential reactions with two different E2s. An initiating E2 ligates ubiquitin to an E3-bound substrate. Another E2 grows a polyubiquitin chain on the ubiquitin-primed substrate through poorly defined mechanisms. Here we show that human APC's RING domain is repurposed for dual functions in polyubiquitination. The canonical RING surface activates an initiating E2-ubiquitin intermediate for substrate modification. However, APC engages and activates its specialized ubiquitin chain-elongating E2 UBE2S in ways that differ from current paradigms. During chain assembly, a distinct APC11 RING surface helps deliver a substrate-linked ubiquitin to accept another ubiquitin from UBE2S. Our data define mechanisms of APC/UBE2S-mediated polyubiquitination, reveal diverse functions of RING E3s and E2s, and provide a framework for understanding distinctive RING E3 features specifying ubiquitin chain elongation. Twit Text FOAVip Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25306923 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25306923 #FOAvip English Wikipedia <ref>{{Cite pmid|25306923 }}</ref> Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly #MMPMID25306923 Brown NG ; Watson ER ; Weissmann F ; Jarvis MA ; VanderLinden R ; Grace CRR ; Frye JJ ; Qiao R ; Dube P ; Petzold G ; Cho SE ; Alsharif O ; Bao J ; Davidson IF ; Zheng JJ ; Nourse A ; Kurinov I ; Peters JM ; Stark H ; Schulman BA Mol Cell 2014[Oct]; 56 (2 ): 246-260 PMID25306923 show ga Polyubiquitination by E2 and E3 enzymes is a predominant mechanism regulating protein function. Some RING E3s, including anaphase-promoting complex/cyclosome (APC), catalyze polyubiquitination by sequential reactions with two different E2s. An initiating E2 ligates ubiquitin to an E3-bound substrate. Another E2 grows a polyubiquitin chain on the ubiquitin-primed substrate through poorly defined mechanisms. Here we show that human APC's RING domain is repurposed for dual functions in polyubiquitination. The canonical RING surface activates an initiating E2-ubiquitin intermediate for substrate modification. However, APC engages and activates its specialized ubiquitin chain-elongating E2 UBE2S in ways that differ from current paradigms. During chain assembly, a distinct APC11 RING surface helps deliver a substrate-linked ubiquitin to accept another ubiquitin from UBE2S. Our data define mechanisms of APC/UBE2S-mediated polyubiquitination, reveal diverse functions of RING E3s and E2s, and provide a framework for understanding distinctive RING E3 features specifying ubiquitin chain elongation. |*Peptide Biosynthesis, Nucleic Acid-Independent [MESH] |Amino Acid Sequence [MESH] |Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome/*metabolism [MESH] |Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome/*metabolism [MESH] |Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome/metabolism [MESH] |Cell Cycle Checkpoints [MESH] |HeLa Cells [MESH] |Humans [MESH] |Molecular Sequence Data [MESH] |Polyubiquitin/*biosynthesis/genetics [MESH] |Protein Structure, Tertiary [MESH] |Ubiquitin-Conjugating Enzymes/*metabolism [MESH]Mechanism of polyubiquitination by human anaphase-promoting complex: R(epmc).pdf DeepDyve Pubget Overpricing