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10.1016/j.cell.2014.11.013 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.11.013 C4272762!4272762!25483777     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 159 (7): 1524-37 Nephropedia Template TP {{tp|p=25483777|t=2014. B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity |pdf=|usr=}}{{25483777}} gab.com Text B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25483777 #FOAvip The antibody gene mutator activation-induced cytidine deaminase (AID) promiscuously damages oncogenes, leading to chromosomal translocations and tumorigenesis. Why nonimmunoglobulin loci are susceptible to AID activity is unknown. Here, we study AID-mediated lesions in the context of nuclear architecture and the B cell regulome. We show that AID targets are not randomly distributed across the genome but are predominantly grouped within super-enhancers and regulatory clusters. Unexpectedly, in these domains, AID deaminates active promoters and eRNA+ enhancers interconnected in some instances over megabases of linear chromatin. Using genome editing, we demonstrate that 3D-linked targets cooperate to recruit AID-mediated breaks. Furthermore, a comparison of hypermutation in mouse B cells, AID-induced kataegis in human lymphomas, and translocations in MEFs reveals that AID damages different genes in different cell types. Yet, in all cases, the targets are predominantly associated with topological complex, highly transcribed super-enhancers, demonstrating that these compartments are key mediators of AID recruitment. Twit Text FOAVip B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25483777 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25483777 #FOAvip English Wikipedia <ref>{{Cite pmid|25483777}}</ref> B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity #MMPMID25483777 Qian J; Wang Q; Dose M; Pruett N; Kieffer-Kwon KR; Resch W; Liang G; Tang Z; Mathé E; Benner C; Dubois W; Nelson S; Vian L; Oliveira TY; Jankovic M; Hakim O; Gazumyan A; Pavri R; Awasthi P; Song B; Liu G; Chen L; Zhu S; Feigenbaum L; Staudt L; Murre C; Ruan Y; Robbiani DF; Pan-Hammarström Q; Nussenzweig MC; Casellas R Cell 2014[Dec]; 159 (7): 1524-37 PMID25483777show ga The antibody gene mutator activation-induced cytidine deaminase (AID) promiscuously damages oncogenes, leading to chromosomal translocations and tumorigenesis. Why nonimmunoglobulin loci are susceptible to AID activity is unknown. Here, we study AID-mediated lesions in the context of nuclear architecture and the B cell regulome. We show that AID targets are not randomly distributed across the genome but are predominantly grouped within super-enhancers and regulatory clusters. Unexpectedly, in these domains, AID deaminates active promoters and eRNA+ enhancers interconnected in some instances over megabases of linear chromatin. Using genome editing, we demonstrate that 3D-linked targets cooperate to recruit AID-mediated breaks. Furthermore, a comparison of hypermutation in mouse B cells, AID-induced kataegis in human lymphomas, and translocations in MEFs reveals that AID damages different genes in different cell types. Yet, in all cases, the targets are predominantly associated with topological complex, highly transcribed super-enhancers, demonstrating that these compartments are key mediators of AID recruitment. äB Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic(epmc).pdf DeepDyve Pubget Overpricing