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10.1128/MCB.01046-14 http://scihub22266oqcxt.onion/10.1128/MCB.01046-14 C4272432!4272432!25384977     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Biol 2015 ; 35 (2): 437-50 Nephropedia Template TP {{tp|p=25384977|t=2015. Heat Stress-Induced Cup9-Dependent Transcriptional Regulation of SIR2 |pdf=|usr=}}{{25384977}} gab.com Text Heat Stress-Induced Cup9-Dependent Transcriptional Regulation of SIR2 JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25384977 #FOAvip The epigenetic writer Sir2 maintains the heterochromatin state of chromosome in three chromosomal regions, namely, the silent mating type loci, telomeres, and the ribosomal DNA (rDNA). In this study, we demonstrated the mechanism by which Sir2 is regulated under heat stress. Our study reveals that a transient heat shock causes a drastic reduction in the SIR2 transcript which results in sustained failure to initiate silencing for as long as 90 generations. Hsp82 overexpression, which is the usual outcome of heat shock treatment, leads to a similar downregulation of SIR2 transcription. Using a series of genetic experiments, we have established that heat shock or Hsp82 overexpression causes upregulation of CUP9 that, in turn, represses SIR2 transcription by binding to its upstream activator sequence. We have mapped the cis regulatory element of SIR2. Our study shows that the deletion of cup9 causes reversal of the Hsp82 overexpression phenotype and upregulation of SIR2 expression in heat-induced Hsp82-overexpressing cells. On the other hand, we found that Cup9 overexpression represses SIR2 transcription and leads to a failure in the establishment of heterochromatin. The results of our study highlight the mechanism by which environmental factors amend the epigenetic configuration of chromatin. Twit Text FOAVip Heat Stress-Induced Cup9-Dependent Transcriptional Regulation of SIR2 ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25384977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25384977 #FOAvip English Wikipedia <ref>{{Cite pmid|25384977}}</ref> Heat Stress-Induced Cup9-Dependent Transcriptional Regulation of SIR2 #MMPMID25384977 Laskar S; K S; Bhattacharyya MK; Nair AS; Dhar P; Bhattacharyya S Mol Cell Biol 2015[Jan]; 35 (2): 437-50 PMID25384977show ga The epigenetic writer Sir2 maintains the heterochromatin state of chromosome in three chromosomal regions, namely, the silent mating type loci, telomeres, and the ribosomal DNA (rDNA). In this study, we demonstrated the mechanism by which Sir2 is regulated under heat stress. Our study reveals that a transient heat shock causes a drastic reduction in the SIR2 transcript which results in sustained failure to initiate silencing for as long as 90 generations. Hsp82 overexpression, which is the usual outcome of heat shock treatment, leads to a similar downregulation of SIR2 transcription. Using a series of genetic experiments, we have established that heat shock or Hsp82 overexpression causes upregulation of CUP9 that, in turn, represses SIR2 transcription by binding to its upstream activator sequence. We have mapped the cis regulatory element of SIR2. Our study shows that the deletion of cup9 causes reversal of the Hsp82 overexpression phenotype and upregulation of SIR2 expression in heat-induced Hsp82-overexpressing cells. On the other hand, we found that Cup9 overexpression represses SIR2 transcription and leads to a failure in the establishment of heterochromatin. The results of our study highlight the mechanism by which environmental factors amend the epigenetic configuration of chromatin. äHeat Stress-Induced Cup9-Dependent Transcriptional Regulation of SIR2 (epmc).pdf DeepDyve Pubget Overpricing