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10.1038/nm.3484 http://scihub22266oqcxt.onion/10.1038/nm.3484 C4271542!4271542!24880615     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2014 ; 20 (7): 778-84 Nephropedia Template TP {{tp|p=24880615|t=2014. On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles |pdf=|usr=}}{{24880615}} gab.com Text On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=24880615 #FOAvip Chemoradiation-resistant cancers limit treatment efficacy and safety. We show here the cancer cell?specific, on-demand intracellular amplification of chemotherapy and chemoradiation therapy via gold nanoparticle? and laser pulse?induced mechanical intracellular impact. Cancer aggressiveness promotes the clustering of drug nanocarriers and gold nanoparticles in cancer cells. This cluster, upon exposure to a laser pulse, generates a plasmonic nanobubble, the mechanical explosion that destroys the host cancer cell or ejects the drug into its cytoplasm by disrupting the liposome and endosome. The same cluster locally amplifies external X-rays. Intracellular synergy of the mechanical impact of plasmonic nanobubble, ejected drug and amplified X-rays improves the efficacy of standard chemoradiation in resistant and aggressive head and neck cancer by 100-fold in vitro and 17-fold in vivo, reduces the effective entry doses of drugs and X-rays to 2?6% of their clinical doses and efficiently spares normal cells. The developed quadrapeutics technology combines four clinically validated components and transforms a standard macrotherapy into an intracellular on-demand theranostic microtreatment with radically amplified therapeutic efficacy and specificity. Twit Text FOAVip On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=24880615 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24880615 #FOAvip English Wikipedia <ref>{{Cite pmid|24880615}}</ref> On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles #MMPMID24880615 Lukianova-Hleb EY; Ren X; Sawant RR; Wu X; Torchilin VP; Lapotko DO Nat Med 2014[Jul]; 20 (7): 778-84 PMID24880615show ga Chemoradiation-resistant cancers limit treatment efficacy and safety. We show here the cancer cell?specific, on-demand intracellular amplification of chemotherapy and chemoradiation therapy via gold nanoparticle? and laser pulse?induced mechanical intracellular impact. Cancer aggressiveness promotes the clustering of drug nanocarriers and gold nanoparticles in cancer cells. This cluster, upon exposure to a laser pulse, generates a plasmonic nanobubble, the mechanical explosion that destroys the host cancer cell or ejects the drug into its cytoplasm by disrupting the liposome and endosome. The same cluster locally amplifies external X-rays. Intracellular synergy of the mechanical impact of plasmonic nanobubble, ejected drug and amplified X-rays improves the efficacy of standard chemoradiation in resistant and aggressive head and neck cancer by 100-fold in vitro and 17-fold in vivo, reduces the effective entry doses of drugs and X-rays to 2?6% of their clinical doses and efficiently spares normal cells. The developed quadrapeutics technology combines four clinically validated components and transforms a standard macrotherapy into an intracellular on-demand theranostic microtreatment with radically amplified therapeutic efficacy and specificity. äOn-demand intracellular amplification of chemoradiation with cancer-sp(epmc).pdf DeepDyve Pubget Overpricing