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10.1088/1478-3975/11/6/065001 http://scihub22266oqcxt.onion/10.1088/1478-3975/11/6/065001 C4271519!4271519 !25426818     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25426818 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cancerous epithelial cell lines shed extracellular vesicles with a bimodal size distribution that is sensitive to glutamine inhibition |pdf=|usr=}}{{25426818 }} gab.com Text Cancerous epithelial cell lines shed extracellular vesicles with a bimodal size distribution that is sensitive to glutamine inhibition JO: Phys Biol http://www.kidney.de/pget.php?&tw=1&pmid=25426818 #FOAvip Extracellular shed vesicles (ESVs) facilitate a unique mode of cell-cell communication wherein vesicle uptake can induce a change in the recipient cell's state. Despite the intensity of ESV research, currently reported data represent the bulk characterization of concentrated vesicle samples with little attention paid to heterogeneity. ESV populations likely represent diversity in mechanisms of formation, cargo and size. To better understand ESV subpopulations and the signaling cascades implicated in their formation, we characterize ESV size distributions to identify subpopulations in normal and cancerous epithelial cells. We have discovered that cancer cells exhibit bimodal ESV distributions, one small-diameter and another large-diameter population, suggesting that two mechanisms may govern ESV formation, an exosome population and a cancer-specific microvesicle population. Altered glutamine metabolism in cancer is thought to fuel cancer growth but may also support metastatic niche formation through microvesicle production. We describe the role of a glutaminase inhibitor, compound 968, in ESV production. We have discovered that inhibiting glutamine metabolism significantly impairs large-diameter microvesicle production in cancer cells. Twit Text FOAVip Cancerous epithelial cell lines shed extracellular vesicles with a bimodal size distribution that is sensitive to glutamine inhibition ????Phys Biol http://www.kidney.de/pget.php?&tw=1&pmid=25426818 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25426818 #FOAvip English Wikipedia <ref>{{Cite pmid|25426818 }}</ref> Cancerous epithelial cell lines shed extracellular vesicles with a bimodal size distribution that is sensitive to glutamine inhibition #MMPMID25426818 Santana SM ; Antonyak MA ; Cerione RA ; Kirby BJ Phys Biol 2014[Nov]; 11 (6 ): 065001 PMID25426818 show ga Extracellular shed vesicles (ESVs) facilitate a unique mode of cell-cell communication wherein vesicle uptake can induce a change in the recipient cell's state. Despite the intensity of ESV research, currently reported data represent the bulk characterization of concentrated vesicle samples with little attention paid to heterogeneity. ESV populations likely represent diversity in mechanisms of formation, cargo and size. To better understand ESV subpopulations and the signaling cascades implicated in their formation, we characterize ESV size distributions to identify subpopulations in normal and cancerous epithelial cells. We have discovered that cancer cells exhibit bimodal ESV distributions, one small-diameter and another large-diameter population, suggesting that two mechanisms may govern ESV formation, an exosome population and a cancer-specific microvesicle population. Altered glutamine metabolism in cancer is thought to fuel cancer growth but may also support metastatic niche formation through microvesicle production. We describe the role of a glutaminase inhibitor, compound 968, in ESV production. We have discovered that inhibiting glutamine metabolism significantly impairs large-diameter microvesicle production in cancer cells. |Cell Communication/drug effects/*physiology [MESH] |Cell Culture Techniques [MESH] |Cell Line, Tumor [MESH] |Enzyme Inhibitors/pharmacology [MESH] |Epithelial Cells/drug effects/enzymology/*metabolism/pathology [MESH] |Exosomes/drug effects/enzymology/metabolism/pathology [MESH] |Extracellular Space/drug effects/enzymology/*metabolism [MESH] |Glutaminase/analysis [MESH] |Glutamine/*antagonists & inhibitors [MESH] |Humans [MESH]Cancerous epithelial cell lines shed extracellular vesicles with a bim(epmc).pdf DeepDyve Pubget Overpricing