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10.1074/jbc.M114.596411

http://scihub22266oqcxt.onion/10.1074/jbc.M114.596411
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suck abstract from ncbi


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pmid25371204      J+Biol+Chem 2014 ; 289 (51): 35633-43
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  • The Anti-proliferative Function of the TGF-?1 Signaling Pathway Involves the Repression of the Oncogenic TBX2 by Its Homologue TBX3* #MMPMID25371204
  • Li J; Ballim D; Rodriguez M; Cui R; Goding CR; Teng H; Prince S
  • J Biol Chem 2014[Dec]; 289 (51): 35633-43 PMID25371204show ga
  • Background: The transcription factor TBX3 regulates the anti-proliferative function of the TGF-?1 pathway but its downstream target(s) responsible for this is unknown.Results: TBX3 downstream of TGF-?1 signaling represses TBX2 to inhibit proliferation.Conclusion: The down-regulation of TBX2 is required for the anti-proliferative function of the TGF-?1-TBX3 axis.Significance: This study sheds light on the mechanisms involved in the anti-proliferative role of TGF-?1.
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