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10.1074/jbc.M114.597740 http://scihub22266oqcxt.onion/10.1074/jbc.M114.597740 C4271240!4271240 !25378389     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25378389 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2014 ; 289 (51 ): 35570-81 Nephropedia Template TP {{tp|p=25378389 |t=2014. Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH Biological Implications |pdf=|usr=}}{{25378389 }} gab.com Text Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH Biological Implications JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25378389 #FOAvip Nitroxyl (HNO), the protonated one-electron reduction product of NO, remains an enigmatic reactive nitrogen species. Its chemical reactivity and biological activity are still not completely understood. HNO donors show biological effects different from NO donors. Although HNO reactivity with molecular oxygen is described in the literature, the product of this reaction has not yet been unambiguously identified. Here we report that the decomposition of HNO donors under aerobic conditions in aqueous solutions at physiological pH leads to the formation of peroxynitrite (ONOO(-)) as a major intermediate. We have specifically detected and quantified ONOO(-) with the aid of boronate probes, e.g. coumarin-7-boronic acid or 4-boronobenzyl derivative of fluorescein methyl ester. In addition to the major phenolic products, peroxynitrite-specific minor products of oxidation of boronate probes were detected under these conditions. Using the competition kinetics method and a set of HNO scavengers, the value of the second order rate constant of the HNO reaction with oxygen (k = 1.8 × 10(4) m(-1) s(-1)) was determined. The rate constant (k = 2 × 10(4) m(-1) s(-1)) was also determined using kinetic simulations. The kinetic parameters of the reactions of HNO with selected thiols, including cysteine, dithiothreitol, N-acetylcysteine, captopril, bovine and human serum albumins, and hydrogen sulfide, are reported. Biological and cardiovascular implications of nitroxyl reactions are discussed. Twit Text FOAVip Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH Biological Implications ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25378389 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25378389 #FOAvip English Wikipedia <ref>{{Cite pmid|25378389 }}</ref> Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH Biological Implications #MMPMID25378389 Smulik R ; D?bski D ; Zielonka J ; Micha?owski B ; Adamus J ; Marcinek A ; Kalyanaraman B ; Sikora A J Biol Chem 2014[Dec]; 289 (51 ): 35570-81 PMID25378389 show ga Nitroxyl (HNO), the protonated one-electron reduction product of NO, remains an enigmatic reactive nitrogen species. Its chemical reactivity and biological activity are still not completely understood. HNO donors show biological effects different from NO donors. Although HNO reactivity with molecular oxygen is described in the literature, the product of this reaction has not yet been unambiguously identified. Here we report that the decomposition of HNO donors under aerobic conditions in aqueous solutions at physiological pH leads to the formation of peroxynitrite (ONOO(-)) as a major intermediate. We have specifically detected and quantified ONOO(-) with the aid of boronate probes, e.g. coumarin-7-boronic acid or 4-boronobenzyl derivative of fluorescein methyl ester. In addition to the major phenolic products, peroxynitrite-specific minor products of oxidation of boronate probes were detected under these conditions. Using the competition kinetics method and a set of HNO scavengers, the value of the second order rate constant of the HNO reaction with oxygen (k = 1.8 × 10(4) m(-1) s(-1)) was determined. The rate constant (k = 2 × 10(4) m(-1) s(-1)) was also determined using kinetic simulations. The kinetic parameters of the reactions of HNO with selected thiols, including cysteine, dithiothreitol, N-acetylcysteine, captopril, bovine and human serum albumins, and hydrogen sulfide, are reported. Biological and cardiovascular implications of nitroxyl reactions are discussed. |Acetylcysteine/chemistry [MESH] |Algorithms [MESH] |Animals [MESH] |Boron Compounds/chemistry [MESH] |Boronic Acids/chemistry [MESH] |Captopril/chemistry [MESH] |Cattle [MESH] |Chromatography, High Pressure Liquid [MESH] |Coumarins/chemistry [MESH] |Cysteine/chemistry [MESH] |Dithiothreitol/chemistry [MESH] |Humans [MESH] |Hydrogen Sulfide/chemistry [MESH] |Hydrogen-Ion Concentration [MESH] |Kinetics [MESH] |Mass Spectrometry [MESH] |Models, Chemical [MESH] |Nitrogen Oxides/*chemistry [MESH] |Oxidation-Reduction [MESH] |Oxygen/*chemistry [MESH] |Peroxynitrous Acid/*chemistry [MESH] |Serum Albumin/chemistry [MESH] |Spectrophotometry [MESH]Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at(epmc).pdf DeepDyve Pubget Overpricing