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Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Biol+Chem 2014 ; 289 (51): 35561-9 Nephropedia Template TP
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Human Memory, but Not Naive, CD4+ T Cells Expressing Transcription Factor T-bet Might Drive Rapid Cytokine Production* #MMPMID25378399
Yu Sf; Zhang Yn; Yang By; Wu Cy
J Biol Chem 2014[Dec]; 289 (51): 35561-9 PMID25378399show ga
Background: Human memory CD4+ T cells mediate adaptive immune responses via rapidly producing effector cytokines.Results: Memory CD4+ T cells highly express T-bet, which is closely correlated with IFN-? production.Conclusion: Pre-existence and nuclear mobilization of T-bet in memory CD4+ T cells contribute to regulating the rapid production of IFN-?.Significance: We declared a possible transcriptional mechanism for rapid production of cytokines by memory CD4+ T cells.