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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Biol+Chem 2014 ; 289 (51): 35503-16 Nephropedia Template TP
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Hes3 Is Expressed in the Adult Pancreatic Islet and Regulates Gene Expression, Cell Growth, and Insulin Release* #MMPMID25371201
Masjkur J; Arps-Forker C; Poser SW; Nikolakopoulou P; Toutouna L; Chenna R; Chavakis T; Chatzigeorgiou A; Chen LS; Dubrovska A; Choudhary P; Uphues I; Mark M; Bornstein SR; Androutsellis-Theotokis A
J Biol Chem 2014[Dec]; 289 (51): 35503-16 PMID25371201show ga
Background: The transcription factor Hes3 regulates the growth of neural and brain cancer stem cells.Results: Hes3 regulates growth, gene expression, evoked insulin release in cultured insulinoma cells, and sensitivity to streptozotocin in vivo.Conclusion: Hes3 is a novel regulator of cellular functions of importance in diabetes.Significance: Introducing Hes3 and its regulators in diabetes research may provide new opportunities for the design of novel therapeutics.