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10.1074/jbc.M114.590687

http://scihub22266oqcxt.onion/10.1074/jbc.M114.590687
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C4271235!4271235!25371201
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suck abstract from ncbi


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pmid25371201      J+Biol+Chem 2014 ; 289 (51): 35503-16
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  • Hes3 Is Expressed in the Adult Pancreatic Islet and Regulates Gene Expression, Cell Growth, and Insulin Release* #MMPMID25371201
  • Masjkur J; Arps-Forker C; Poser SW; Nikolakopoulou P; Toutouna L; Chenna R; Chavakis T; Chatzigeorgiou A; Chen LS; Dubrovska A; Choudhary P; Uphues I; Mark M; Bornstein SR; Androutsellis-Theotokis A
  • J Biol Chem 2014[Dec]; 289 (51): 35503-16 PMID25371201show ga
  • Background: The transcription factor Hes3 regulates the growth of neural and brain cancer stem cells.Results: Hes3 regulates growth, gene expression, evoked insulin release in cultured insulinoma cells, and sensitivity to streptozotocin in vivo.Conclusion: Hes3 is a novel regulator of cellular functions of importance in diabetes.Significance: Introducing Hes3 and its regulators in diabetes research may provide new opportunities for the design of novel therapeutics.
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