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10.1074/jbc.M114.621599

http://scihub22266oqcxt.onion/10.1074/jbc.M114.621599
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C4271231!4271231!25359775
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suck abstract from ncbi


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pmid25359775      J+Biol+Chem 2014 ; 289 (51): 35456-67
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  • Isoquercitrin Suppresses Colon Cancer Cell Growth in Vitro by Targeting the Wnt/?-Catenin Signaling Pathway* #MMPMID25359775
  • Amado NG; Predes D; Fonseca BF; Cerqueira DM; Reis AH; Dudenhoeffer AC; Borges HL; Mendes FA; Abreu JG
  • J Biol Chem 2014[Dec]; 289 (51): 35456-67 PMID25359775show ga
  • Background: Flavonoids are natural compounds capable of modulating signaling pathways in a variety of biological processes.Results: Isoquercitrin inhibits canonical Wnt signaling in Xenopus embryos downstream of ?-catenin and impairs the growth in colon cancer cells in vitro, without cytotoxic effects.Conclusion: Isoquercitrin inhibits Wnt/?-catenin pathway and the growth of colon cancer cells in vitro.Significance: Isoquercitrin should be further investigated as a potential anti-tumoral agent targeting Wnt/?-catenin signaling.
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