Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1074/jbc.M114.621599 http://scihub22266oqcxt.onion/10.1074/jbc.M114.621599 C4271231!4271231 !25359775     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25359775 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25359775 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2014 ; 289 (51 ): 35456-67 Nephropedia Template TP {{tp|p=25359775 |t=2014. Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/?-catenin signaling pathway |pdf=|usr=}}{{25359775 }} gab.com Text Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/ -catenin signaling pathway JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25359775 #FOAvip Flavonoids are plant-derived polyphenolic molecules that have potential biological effects including anti-oxidative, anti-inflammatory, anti-viral, and anti-tumoral effects. These effects are related to the ability of flavonoids to modulate signaling pathways, such as the canonical Wnt signaling pathway. This pathway controls many aspects of embryonic development and tissue maintenance and has been found to be deregulated in a range of human cancers. We performed several in vivo assays in Xenopus embryos, a functional model of canonical Wnt signaling studies, and also used in vitro models, to investigate whether isoquercitrin affects Wnt/?-catenin signaling. Our data provide strong support for an inhibitory effect of isoquercitrin on Wnt/?-catenin, where the flavonoid acts downstream of ?-catenin translocation to the nuclei. Isoquercitrin affects Xenopus axis establishment, reverses double axes and the LiCl hyperdorsalization phenotype, and reduces Xnr3 expression. In addition, this flavonoid shows anti-tumoral effects on colon cancer cells (SW480, DLD-1, and HCT116), whereas exerting no significant effect on non-tumor colon cell (IEC-18), suggesting a specific effect in tumor cells in vitro. Taken together, our data indicate that isoquercitrin is an inhibitor of Wnt/?-catenin and should be further investigated as a potential novel anti-tumoral agent. Twit Text FOAVip Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/ -catenin signaling pathway ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25359775 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25359775 #FOAvip English Wikipedia <ref>{{Cite pmid|25359775 }}</ref> Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/?-catenin signaling pathway #MMPMID25359775 Amado NG ; Predes D ; Fonseca BF ; Cerqueira DM ; Reis AH ; Dudenhoeffer AC ; Borges HL ; Mendes FA ; Abreu JG J Biol Chem 2014[Dec]; 289 (51 ): 35456-67 PMID25359775 show ga Flavonoids are plant-derived polyphenolic molecules that have potential biological effects including anti-oxidative, anti-inflammatory, anti-viral, and anti-tumoral effects. These effects are related to the ability of flavonoids to modulate signaling pathways, such as the canonical Wnt signaling pathway. This pathway controls many aspects of embryonic development and tissue maintenance and has been found to be deregulated in a range of human cancers. We performed several in vivo assays in Xenopus embryos, a functional model of canonical Wnt signaling studies, and also used in vitro models, to investigate whether isoquercitrin affects Wnt/?-catenin signaling. Our data provide strong support for an inhibitory effect of isoquercitrin on Wnt/?-catenin, where the flavonoid acts downstream of ?-catenin translocation to the nuclei. Isoquercitrin affects Xenopus axis establishment, reverses double axes and the LiCl hyperdorsalization phenotype, and reduces Xnr3 expression. In addition, this flavonoid shows anti-tumoral effects on colon cancer cells (SW480, DLD-1, and HCT116), whereas exerting no significant effect on non-tumor colon cell (IEC-18), suggesting a specific effect in tumor cells in vitro. Taken together, our data indicate that isoquercitrin is an inhibitor of Wnt/?-catenin and should be further investigated as a potential novel anti-tumoral agent. |Active Transport, Cell Nucleus/drug effects [MESH] |Animals [MESH] |Antineoplastic Agents/pharmacology [MESH] |Blotting, Western [MESH] |Body Patterning/drug effects/genetics [MESH] |Cell Line [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Cell Nucleus/drug effects/metabolism [MESH] |Cell Proliferation/*drug effects [MESH] |Colonic Neoplasms/metabolism/pathology [MESH] |Early Growth Response Protein 2/genetics [MESH] |Embryo, Nonmammalian/drug effects/embryology/metabolism [MESH] |Gene Expression Regulation, Developmental [MESH] |HCT116 Cells [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |In Situ Hybridization [MESH] |Lithium Chloride/pharmacology [MESH] |Quercetin/*analogs & derivatives/pharmacology [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Wnt Signaling Pathway/*drug effects/genetics [MESH] |Xenopus Proteins/genetics [MESH] |Xenopus/embryology/genetics/metabolism [MESH]Isoquercitrin suppresses colon cancer cell growth in vitro by targetin(epmc).pdf DeepDyve Pubget Overpricing