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10.1074/jbc.M114.587840

http://scihub22266oqcxt.onion/10.1074/jbc.M114.587840
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C4271222!4271222!25339176
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suck abstract from ncbi


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pmid25339176      J+Biol+Chem 2014 ; 289 (51): 35363-75
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  • Activation of Glycogen Synthase Kinase 3? Ameliorates Diabetes-induced Kidney Injury* #MMPMID25339176
  • Mariappan MM; Prasad S; D'Silva K; Cedillo E; Sataranatarajan K; Barnes JL; Choudhury GG; Kasinath BS
  • J Biol Chem 2014[Dec]; 289 (51): 35363-75 PMID25339176show ga
  • Background: High glucose-induced matrix protein synthesis in renal cells requires glycogen synthase kinase 3? (GSK3?) inactivation.Results: Sodium nitroprusside (SNP) activated GSK3? and inhibited diabetes-induced kidney hypertrophy, matrix deposition, and albuminuria in mice without changing blood glucose.Conclusion: Activation of GSK3? by SNP ameliorates diabetic kidney injury.Significance: GSK3? may be a novel target for intervention in diabetic kidney disease.
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