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10.1074/jbc.M114.597187

http://scihub22266oqcxt.onion/10.1074/jbc.M114.597187
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C4271209!4271209!25371197
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suck abstract from ncbi


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pmid25371197      J+Biol+Chem 2014 ; 289 (51): 35205-14
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  • TAK1-ECSIT-TRAF6 Complex Plays a Key Role in the TLR4 Signal to Activate NF-?B* #MMPMID25371197
  • Wi SM; Moon G; Kim J; Kim ST; Shim JH; Chun E; Lee KY
  • J Biol Chem 2014[Dec]; 289 (51): 35205-14 PMID25371197show ga
  • Background: ECSIT as a multifunctional protein is involved in TLR signals. However, its regulatory function is not fully characterized.Results: ECSIT forms a high molecular endogenous complex including TAK1 and TRAF6, and that leads to activation of TAK1 and NF-?B.Conclusion: TAK1-ECSIT-TRAF6 complex plays an essential role in TLR4 signals.Significance: This study identifies a new regulatory role of ECSIT in TLR4-mediated signaling.
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