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10.1074/jbc.M114.580159

http://scihub22266oqcxt.onion/10.1074/jbc.M114.580159
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C4271207!4271207!25355314
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suck abstract from ncbi


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pmid25355314      J+Biol+Chem 2014 ; 289 (51): 35182-92
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  • Depletion of the Central Metabolite NAD Leads to Oncosis-mediated Cell Death* #MMPMID25355314
  • Del Nagro C; Xiao Y; Rangell L; Reichelt M; O'Brien T
  • J Biol Chem 2014[Dec]; 289 (51): 35182-92 PMID25355314show ga
  • Background: Depletion of NAD is a novel therapeutic strategy in oncology.Results: NAD depletion leads to loss of ATP and plasma membrane homeostasis.Conclusion: Although cells display evidence of apoptosis and autophagy, they predominantly die by oncosis caused by loss of ATP.Significance: We have identified a common pathway leading to cell death in response to NAD depletion.
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