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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Neuron 2014 ; 84 (6): 1143-56 Nephropedia Template TP
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The orbitofrontal oracle: cortical mechanisms for the prediction and evaluation of specific behavioral outcomes #MMPMID25521376
Rudebeck PH; Murray EA
Neuron 2014[Dec]; 84 (6): 1143-56 PMID25521376show ga
The orbitofrontal cortex (OFC) has long been associated with the flexible control of behavior and concepts such as behavioral inhibition, self-control and emotional regulation. These ideas emphasize the suppression of behaviors and emotions, but OFC?s affirmative functions have remained enigmatic. Here we review recent work that has advanced our understanding of this prefrontal area and how its functions are shaped through interaction with subcortical structures such as the amygdala. Recent findings have overturned theories emphasizing behavioral inhibition as OFC?s fundamental function. Instead, new findings indicate that OFC provides predictions about specific outcomes associated with stimuli, choices and actions, especially their moment-to-moment value based on current internal states. OFC function thereby encompasses a broad representation or model of an individual?s sensory milieu and potential actions, along with their relationship to likely behavioral outcomes.