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2014 ; 84
(6
): 1143-56
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English Wikipedia
The orbitofrontal oracle: cortical mechanisms for the prediction and evaluation
of specific behavioral outcomes
#MMPMID25521376
Rudebeck PH
; Murray EA
Neuron
2014[Dec]; 84
(6
): 1143-56
PMID25521376
show ga
The orbitofrontal cortex (OFC) has long been associated with the flexible control
of behavior and concepts such as behavioral inhibition, self-control, and
emotional regulation. These ideas emphasize the suppression of behaviors and
emotions, but OFC's affirmative functions have remained enigmatic. Here we review
recent work that has advanced our understanding of this prefrontal area and how
its functions are shaped through interaction with subcortical structures such as
the amygdala. Recent findings have overturned theories emphasizing behavioral
inhibition as OFC's fundamental function. Instead, new findings indicate that OFC
provides predictions about specific outcomes associated with stimuli, choices,
and actions, especially their moment-to-moment value based on current internal
states. OFC function thereby encompasses a broad representation or model of an
individual's sensory milieu and potential actions, along with their relationship
to likely behavioral outcomes.