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10.1093/bib/bbt053 http://scihub22266oqcxt.onion/10.1093/bib/bbt053 C4271068!4271068!23956260     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brief+Bioinform 2014 ; 15 (6): 919-28 Nephropedia Template TP {{tp|p=23956260|t=2014. The dilemma of choosing the ideal permutation strategy while estimating statistical significance of genome-wide enrichment |pdf=|usr=}}{{23956260}} gab.com Text The dilemma of choosing the ideal permutation strategy while estimating statistical significance of genome-wide enrichment JO: Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=23956260 #FOAvip Integrative analyses of genomic, epigenomic and transcriptomic features for human and various model organisms have revealed that many such features are nonrandomly distributed in the genome. Significant enrichment (or depletion) of genomic features is anticipated to be biologically important. Detection of genomic regions having enrichment of certain features and estimation of corresponding statistical significance rely on the expected null distribution generated by a permutation model. We discuss different genome-wide permutation approaches, present examples where the permutation strategy affects the null model and show that the confidence in estimating statistical significance of genome-wide enrichment might depend on the choice of the permutation approach. In those cases, where biologically relevant constraints are unclear, it is preferable to examine whether key conclusions are consistent, irrespective of the choice of the randomization strategy. Twit Text FOAVip The dilemma of choosing the ideal permutation strategy while estimating statistical significance of genome-wide enrichment ????Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=23956260 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23956260 #FOAvip English Wikipedia <ref>{{Cite pmid|23956260}}</ref> The dilemma of choosing the ideal permutation strategy while estimating statistical significance of genome-wide enrichment #MMPMID23956260 De S; Pedersen BS; Kechris K Brief Bioinform 2014[Nov]; 15 (6): 919-28 PMID23956260show ga Integrative analyses of genomic, epigenomic and transcriptomic features for human and various model organisms have revealed that many such features are nonrandomly distributed in the genome. Significant enrichment (or depletion) of genomic features is anticipated to be biologically important. Detection of genomic regions having enrichment of certain features and estimation of corresponding statistical significance rely on the expected null distribution generated by a permutation model. We discuss different genome-wide permutation approaches, present examples where the permutation strategy affects the null model and show that the confidence in estimating statistical significance of genome-wide enrichment might depend on the choice of the permutation approach. In those cases, where biologically relevant constraints are unclear, it is preferable to examine whether key conclusions are consistent, irrespective of the choice of the randomization strategy. äThe dilemma of choosing the ideal permutation strategy while estimatin(epmc).pdf DeepDyve Pubget Overpricing