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10.1016/j.trsl.2014.06.004 http://scihub22266oqcxt.onion/10.1016/j.trsl.2014.06.004 C4270958!4270958 !25005737     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25005737 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Transl+Res 2015 ; 165 (4 ): 499-504 Nephropedia Template TP {{tp|p=25005737 |t=2015. The proteinuria-hypertriglyceridemia connection as a basis for novel therapeutics for nephrotic syndrome |pdf=|usr=}}{{25005737 }} gab.com Text The proteinuria-hypertriglyceridemia connection as a basis for novel therapeutics for nephrotic syndrome JO: Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=25005737 #FOAvip The development of new and specific treatment options for kidney disease in general and glomerular diseases in specific has lagged behind other fields like heart disease and cancer. As a result, nephrologists have had to test and adapt therapeutics developed for other indications to treat glomerular diseases. One of the major factors contributing to this inertia has been the poor understanding of disease mechanisms. One way to elucidate these disease mechanisms is to study the association between the cardinal manifestations of glomerular diseases. Because many of these patients develop nephrotic syndrome, understanding the relationship of proteinuria, the primary driver in this syndrome, with hypoalbuminemia, hypercholesterolemia, hypertriglyceridemia, edema, and lipiduria could provide valuable insight. The recent unraveling of the relationship between proteinuria and hypertriglyceridemia mediated by free fatty acids, albumin, and the secreted glycoprotein angiopoietin-like 4 (Angptl4) offers a unique opportunity to develop novel therapeutics for glomerular diseases. In this review, the therapeutic potential of mutant forms of Angptl4 in reducing proteinuria and, as a consequence, alleviating the other manifestations of nephrotic syndrome is discussed. Twit Text FOAVip The proteinuria-hypertriglyceridemia connection as a basis for novel therapeutics for nephrotic syndrome ????Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=25005737 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25005737 #FOAvip English Wikipedia <ref>{{Cite pmid|25005737 }}</ref> The proteinuria-hypertriglyceridemia connection as a basis for novel therapeutics for nephrotic syndrome #MMPMID25005737 Clement LC ; Macé C ; Del Nogal Avila M ; Marshall CB ; Chugh SS Transl Res 2015[Apr]; 165 (4 ): 499-504 PMID25005737 show ga The development of new and specific treatment options for kidney disease in general and glomerular diseases in specific has lagged behind other fields like heart disease and cancer. As a result, nephrologists have had to test and adapt therapeutics developed for other indications to treat glomerular diseases. One of the major factors contributing to this inertia has been the poor understanding of disease mechanisms. One way to elucidate these disease mechanisms is to study the association between the cardinal manifestations of glomerular diseases. Because many of these patients develop nephrotic syndrome, understanding the relationship of proteinuria, the primary driver in this syndrome, with hypoalbuminemia, hypercholesterolemia, hypertriglyceridemia, edema, and lipiduria could provide valuable insight. The recent unraveling of the relationship between proteinuria and hypertriglyceridemia mediated by free fatty acids, albumin, and the secreted glycoprotein angiopoietin-like 4 (Angptl4) offers a unique opportunity to develop novel therapeutics for glomerular diseases. In this review, the therapeutic potential of mutant forms of Angptl4 in reducing proteinuria and, as a consequence, alleviating the other manifestations of nephrotic syndrome is discussed. |Angiopoietin-Like Protein 4 [MESH] |Angiopoietins/genetics/pharmacology [MESH] |Humans [MESH] |Hypertriglyceridemia/*complications [MESH] |Nephrotic Syndrome/*drug therapy/etiology [MESH] |Proteinuria/*complications [MESH]The proteinuria-hypertriglyceridemia connection as a basis for novel t(epmc).pdf DeepDyve Pubget Overpricing