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10.1038/cgt.2014.57 http://scihub22266oqcxt.onion/10.1038/cgt.2014.57 C4270822!4270822!25412645     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Gene+Ther 2014 ; 21 (12): 518-25 Nephropedia Template TP {{tp|p=25412645|t=2014. Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo |pdf=|usr=}}{{25412645}} gab.com Text Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo JO: Cancer Gene Ther http://www.kidney.de/pget.php?&tw=1&pmid=25412645 #FOAvip Carcinoids are slow-growing neuroendocrine tumors (NETs) that are characterized by hormone overproduction; surgery is currently the only option for treatment. Activation of the Notch pathway has previously been shown to have a role in tumor suppression in NETs. The marine-derived thiodepsipeptide thiocoraline was investigated in vitro in two carcinoid cell lines (BON and H727). Carcinoid cells treated with nanomolar concentrations of thiocoraline resulted in a decrease in cell proliferation and an alteration of malignant phenotype evidenced by decrease of NET markers, ASCL-1, CgA, and NSE. Western blot analysis demonstrated the activation of Notch1 on the protein level in BON cells. Additionally, thiocoraline activated downstream Notch targets HES1, HES5, and HEY2. Thiocoraline effectively suppressed carcinoid cell growth by promoting cell cycle arrest in BON and H727 cells. An in vivo study demonstrated that thiocoraline, formulated with polymeric micelles, slowed carcinoid tumor progression. Thus, the therapeutic potential of thiocoraline, which induced activation of the Notch pathway, in carcinoid tumors was demonstrated. Twit Text FOAVip Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo ????Cancer Gene Ther http://www.kidney.de/pget.php?&tw=1&pmid=25412645 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25412645 #FOAvip English Wikipedia <ref>{{Cite pmid|25412645}}</ref> Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo #MMPMID25412645 Wyche TP; Dammalapati A; Cho H; Harrison AD; Kwon GS; Chen H; Bugni TS; Jaskula-Sztul R Cancer Gene Ther 2014[Dec]; 21 (12): 518-25 PMID25412645show ga Carcinoids are slow-growing neuroendocrine tumors (NETs) that are characterized by hormone overproduction; surgery is currently the only option for treatment. Activation of the Notch pathway has previously been shown to have a role in tumor suppression in NETs. The marine-derived thiodepsipeptide thiocoraline was investigated in vitro in two carcinoid cell lines (BON and H727). Carcinoid cells treated with nanomolar concentrations of thiocoraline resulted in a decrease in cell proliferation and an alteration of malignant phenotype evidenced by decrease of NET markers, ASCL-1, CgA, and NSE. Western blot analysis demonstrated the activation of Notch1 on the protein level in BON cells. Additionally, thiocoraline activated downstream Notch targets HES1, HES5, and HEY2. Thiocoraline effectively suppressed carcinoid cell growth by promoting cell cycle arrest in BON and H727 cells. An in vivo study demonstrated that thiocoraline, formulated with polymeric micelles, slowed carcinoid tumor progression. Thus, the therapeutic potential of thiocoraline, which induced activation of the Notch pathway, in carcinoid tumors was demonstrated. äThiocoraline activates the Notch pathway in carcinoids and reduces tum(epmc).pdf DeepDyve Pubget Overpricing