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10.1016/j.stem.2014.10.003 http://scihub22266oqcxt.onion/10.1016/j.stem.2014.10.003 C4270016!4270016!25517466     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Stem+Cell 2014 ; 15 (5): 589-604 Nephropedia Template TP {{tp|p=25517466|t=2014. In vivo activation of a conserved microRNA program induces robust mammalian heart regeneration |pdf=|usr=}}{{25517466}} gab.com Text In vivo activation of a conserved microRNA program induces robust mammalian heart regeneration JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=25517466 #FOAvip Heart failure is a leading cause of mortality and morbidity in the developed world, partly because mammals lack the ability to regenerate heart tissue. Whether this is due to evolutionary loss of regenerative mechanisms present in other organisms or to an inability to activate such mechanisms is currently unclear. Here, we decipher mechanisms underlying heart regeneration in adult zebrafish and show that the molecular regulators of this response are conserved in mammals. We identified miR-99/100 and Let-7a/c, and their protein targets smarca5 and fntb, as critical regulators of cardiomyocyte dedifferentiation and heart regeneration in zebrafish. Although human and murine adult cardiomyocytes fail to elicit an endogenous regenerative response following myocardial infarction, we show that in vivo manipulation of this molecular machinery in mice results in cardiomyocyte dedifferentiation and improved heart functionality after injury. These data provide a proof-of-concept for identifying and activating conserved molecular programs to regenerate the damaged heart. Twit Text FOAVip In vivo activation of a conserved microRNA program induces robust mammalian heart regeneration ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=25517466 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25517466 #FOAvip English Wikipedia <ref>{{Cite pmid|25517466}}</ref> In vivo activation of a conserved microRNA program induces robust mammalian heart regeneration #MMPMID25517466 Aguirre A; Montserrat N; Zachiggna S; Nivet E; Hishida T; Krause MN; Kurian L; Ocampo A; Vazquez-Ferrer E; Rodriguez-Esteban C; Kumar S; Moresco J; Yates J; Campistol JM; Sancho-Martinez I; Giacca M; Belmonte JI Cell Stem Cell 2014[Nov]; 15 (5): 589-604 PMID25517466show ga Heart failure is a leading cause of mortality and morbidity in the developed world, partly because mammals lack the ability to regenerate heart tissue. Whether this is due to evolutionary loss of regenerative mechanisms present in other organisms or to an inability to activate such mechanisms is currently unclear. Here, we decipher mechanisms underlying heart regeneration in adult zebrafish and show that the molecular regulators of this response are conserved in mammals. We identified miR-99/100 and Let-7a/c, and their protein targets smarca5 and fntb, as critical regulators of cardiomyocyte dedifferentiation and heart regeneration in zebrafish. Although human and murine adult cardiomyocytes fail to elicit an endogenous regenerative response following myocardial infarction, we show that in vivo manipulation of this molecular machinery in mice results in cardiomyocyte dedifferentiation and improved heart functionality after injury. These data provide a proof-of-concept for identifying and activating conserved molecular programs to regenerate the damaged heart. äIn vivo activation of a conserved microRNA program induces robust mamm(epmc).pdf DeepDyve Pubget Overpricing