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10.1016/j.ccell.2014.09.015 http://scihub22266oqcxt.onion/10.1016/j.ccell.2014.09.015 C4269832!4269832 !25517751     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25517751 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Cell 2014 ; 26 (5 ): 738-53 Nephropedia Template TP {{tp|p=25517751 |t=2014. TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma |pdf=|usr=}}{{25517751 }} gab.com Text TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25517751 #FOAvip Autophagy promotes tumor growth by generating nutrients from the degradation of intracellular structures. Here we establish, using shRNAs, a dominant-negative mutant, and a pharmacologic inhibitor, mefenamic acid (MFA), that the Transient Receptor Potential Melastatin 3 (TRPM3) channel promotes the growth of clear cell renal cell carcinoma (ccRCC) and stimulates MAP1LC3A (LC3A) and MAP1LC3B (LC3B) autophagy. Increased expression of TRPM3 in RCC leads to Ca(2+) influx, activation of CAMKK2, AMPK, and ULK1, and phagophore formation. In addition, TRPM3 Ca(2+) and Zn(2+) fluxes inhibit miR-214, which directly targets LC3A and LC3B. The von Hippel-Lindau tumor suppressor (VHL) represses TRPM3 directly through miR-204 and indirectly through another miR-204 target, Caveolin 1 (CAV1). Twit Text FOAVip TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25517751 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25517751 #FOAvip English Wikipedia <ref>{{Cite pmid|25517751 }}</ref> TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma #MMPMID25517751 Hall DP ; Cost NG ; Hegde S ; Kellner E ; Mikhaylova O ; Stratton Y ; Ehmer B ; Abplanalp WA ; Pandey R ; Biesiada J ; Harteneck C ; Plas DR ; Meller J ; Czyzyk-Krzeska MF Cancer Cell 2014[Nov]; 26 (5 ): 738-53 PMID25517751 show ga Autophagy promotes tumor growth by generating nutrients from the degradation of intracellular structures. Here we establish, using shRNAs, a dominant-negative mutant, and a pharmacologic inhibitor, mefenamic acid (MFA), that the Transient Receptor Potential Melastatin 3 (TRPM3) channel promotes the growth of clear cell renal cell carcinoma (ccRCC) and stimulates MAP1LC3A (LC3A) and MAP1LC3B (LC3B) autophagy. Increased expression of TRPM3 in RCC leads to Ca(2+) influx, activation of CAMKK2, AMPK, and ULK1, and phagophore formation. In addition, TRPM3 Ca(2+) and Zn(2+) fluxes inhibit miR-214, which directly targets LC3A and LC3B. The von Hippel-Lindau tumor suppressor (VHL) represses TRPM3 directly through miR-204 and indirectly through another miR-204 target, Caveolin 1 (CAV1). |*Autophagy [MESH] |Animals [MESH] |Carcinoma, Renal Cell/genetics/metabolism/*pathology [MESH] |Caveolin 1/metabolism [MESH] |Cell Line, Tumor [MESH] |Gene Expression Regulation, Neoplastic [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Kidney Neoplasms/genetics/*pathology [MESH] |Mice, Nude [MESH] |MicroRNAs/*physiology [MESH] |Neoplasm Transplantation [MESH] |Oncogenes [MESH] |RNA Interference [MESH] |TRPM Cation Channels/*genetics/metabolism [MESH] |Tumor Burden [MESH]TRPM3 and miR-204 establish a regulatory circuit that controls oncogen(epmc).pdf DeepDyve Pubget Overpricing