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10.1038/jcbfm.2014.124 http://scihub22266oqcxt.onion/10.1038/jcbfm.2014.124 C4269722!4269722 !25052558     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25052558 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cereb+Blood+Flow+Metab 2014 ; 34 (10 ): 1637-45 Nephropedia Template TP {{tp|p=25052558 |t=2014. Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation |pdf=|usr=}}{{25052558 }} gab.com Text Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation JO: J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=25052558 #FOAvip In our juvenile traumatic brain injury (jTBI) model, emergence of cognitive dysfunctions was observed up to 6 months after trauma. Here we hypothesize that early brain injury induces changes in the neurovascular unit (NVU) that would be associated with amyloid-beta (A?) accumulation. We investigated NVU changes for up to 6 months in a rat jTBI model, with a focus on the efflux protein P-glycoprotein (P-gp) and on the basement membrane proteins perlecan and fibronectin, all known to be involved in A? clearance. Rodent-A? staining is present and increased after jTBI around cerebral blood microvessels, and the diameter of those is decreased by 25% and 34% at 2 and 6 months, respectively, without significant angiogenesis. P-glycoprotein staining in endothelium is decreased by 22% and parallels an increase of perlecan and fibronectin staining around cerebral blood vessels. Altogether, these results strongly suggest that the emergence of long-term behavioral dysfunctions observed in rodent jTBI may be related to endothelial remodeling at the blood-brain barrier alongside vascular dysfunction and altered A? trafficking. This study shows that it is important to consider jTBI as a vascular disorder with long-term consequences on cognitive functions. Twit Text FOAVip Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation ????J Cereb Blood Flow Metab http://www.kidney.de/pget.php?&tw=1&pmid=25052558 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25052558 #FOAvip English Wikipedia <ref>{{Cite pmid|25052558 }}</ref> Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation #MMPMID25052558 Jullienne A ; Roberts JM ; Pop V ; Paul Murphy M ; Head E ; Bix GJ ; Badaut J J Cereb Blood Flow Metab 2014[Oct]; 34 (10 ): 1637-45 PMID25052558 show ga In our juvenile traumatic brain injury (jTBI) model, emergence of cognitive dysfunctions was observed up to 6 months after trauma. Here we hypothesize that early brain injury induces changes in the neurovascular unit (NVU) that would be associated with amyloid-beta (A?) accumulation. We investigated NVU changes for up to 6 months in a rat jTBI model, with a focus on the efflux protein P-glycoprotein (P-gp) and on the basement membrane proteins perlecan and fibronectin, all known to be involved in A? clearance. Rodent-A? staining is present and increased after jTBI around cerebral blood microvessels, and the diameter of those is decreased by 25% and 34% at 2 and 6 months, respectively, without significant angiogenesis. P-glycoprotein staining in endothelium is decreased by 22% and parallels an increase of perlecan and fibronectin staining around cerebral blood vessels. Altogether, these results strongly suggest that the emergence of long-term behavioral dysfunctions observed in rodent jTBI may be related to endothelial remodeling at the blood-brain barrier alongside vascular dysfunction and altered A? trafficking. This study shows that it is important to consider jTBI as a vascular disorder with long-term consequences on cognitive functions. |Amyloid beta-Peptides/*metabolism [MESH] |Animals [MESH] |Blood-Brain Barrier/metabolism/pathology [MESH] |Brain Injuries/metabolism/*pathology [MESH] |Brain/*blood supply/metabolism/*pathology [MESH] |Fibronectins/analysis/metabolism [MESH] |Heparan Sulfate Proteoglycans/analysis/metabolism [MESH] |Male [MESH] |Microcirculation [MESH] |Rats [MESH]Juvenile traumatic brain injury induces long-term perivascular matrix (epmc).pdf DeepDyve Pubget Overpricing