Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1152/ajpheart.00281.2014 http://scihub22266oqcxt.onion/10.1152/ajpheart.00281.2014 C4269697!4269697!25239805     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Heart+Circ+Physiol 2014 ; 307 (12): H1691-704 Nephropedia Template TP {{tp|p=25239805|t=2014. Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction |pdf=|usr=}}{{25239805}} gab.com Text Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction JO: Am J Physiol Heart Circ Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25239805 #FOAvip Discordant myocardial growth and angiogenesis can explain left ventricular (LV) hypertrophy progressing toward heart failure with aging. Sirtuin 1 expression declines with age; therefore we explored the role played by angiogenesis and Sirtuin 1 in the development of cardiomyopathy. We compared the cardiac function of 10- to 15-wk-old (wo), 30?40 wo, and 61?70 wo endothelial Sirtuin 1-deleted (Sirt1endo?/?) mice and their corresponding knockout controls (Sirt1Flox/Flox). After 30?40 wk, Sirt1endo?/? animals exhibited diastolic dysfunction (DD), decreased mRNA expression of Serca2a in the LV, and decreased capillary density compared with control animals despite a similar VEGFa mRNA expression. However, LV fibrosis and hypoxia-inducible factor (HIF)1? expression were not different. The creation of a transverse aortic constriction (TAC) provoked more severe DD and LV fibrosis in Sirt1endo?/? compared with control TAC animals. Although the VEGFa mRNA expression was not different and the protein expression of HIF1? was higher in the Sirt1endo?/? TAC animals, capillary density remained reduced. In cultured endothelial cells administration of Sirtuin 1 inhibitor decreased mRNA expression of VEGF receptors FLT 1 and FLK 1. Ex vivo capillary sprouting from aortic explants showed impaired angiogenic response to VEGF in the Sirt1endo?/? mice. In conclusion, the data demonstrate 1) a defect in angiogenesis preceding development of DD; 2) dispensability of endothelial Sirtuin 1 under unstressed conditions and during normal aging; and 3) impaired angiogenic adaptation and aggravated DD in Sirt1endo?/? mice challenged with LV overload. Twit Text FOAVip Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction ????Am J Physiol Heart Circ Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25239805 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25239805 #FOAvip English Wikipedia <ref>{{Cite pmid|25239805}}</ref> Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction #MMPMID25239805 Maizel J; Xavier S; Chen J; Lin CHS; Vasko R; Goligorsky MS Am J Physiol Heart Circ Physiol 2014[Dec]; 307 (12): H1691-704 PMID25239805show ga Discordant myocardial growth and angiogenesis can explain left ventricular (LV) hypertrophy progressing toward heart failure with aging. Sirtuin 1 expression declines with age; therefore we explored the role played by angiogenesis and Sirtuin 1 in the development of cardiomyopathy. We compared the cardiac function of 10- to 15-wk-old (wo), 30?40 wo, and 61?70 wo endothelial Sirtuin 1-deleted (Sirt1endo?/?) mice and their corresponding knockout controls (Sirt1Flox/Flox). After 30?40 wk, Sirt1endo?/? animals exhibited diastolic dysfunction (DD), decreased mRNA expression of Serca2a in the LV, and decreased capillary density compared with control animals despite a similar VEGFa mRNA expression. However, LV fibrosis and hypoxia-inducible factor (HIF)1? expression were not different. The creation of a transverse aortic constriction (TAC) provoked more severe DD and LV fibrosis in Sirt1endo?/? compared with control TAC animals. Although the VEGFa mRNA expression was not different and the protein expression of HIF1? was higher in the Sirt1endo?/? TAC animals, capillary density remained reduced. In cultured endothelial cells administration of Sirtuin 1 inhibitor decreased mRNA expression of VEGF receptors FLT 1 and FLK 1. Ex vivo capillary sprouting from aortic explants showed impaired angiogenic response to VEGF in the Sirt1endo?/? mice. In conclusion, the data demonstrate 1) a defect in angiogenesis preceding development of DD; 2) dispensability of endothelial Sirtuin 1 under unstressed conditions and during normal aging; and 3) impaired angiogenic adaptation and aggravated DD in Sirt1endo?/? mice challenged with LV overload. äSirtuin 1 ablation in endothelial cells is associated with impaired an(epmc).pdf DeepDyve Pubget Overpricing