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10.1152/ajpheart.00281.2014 http://scihub22266oqcxt.onion/10.1152/ajpheart.00281.2014 C4269697!4269697 !25239805     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25239805 &cmd=llinks): Failed to open stream: HTTP request failed! 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Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction |pdf=|usr=}}{{25239805 }} gab.com Text Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction JO: Am J Physiol Heart Circ Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25239805 #FOAvip Discordant myocardial growth and angiogenesis can explain left ventricular (LV) hypertrophy progressing toward heart failure with aging. Sirtuin 1 expression declines with age; therefore we explored the role played by angiogenesis and Sirtuin 1 in the development of cardiomyopathy. We compared the cardiac function of 10- to 15-wk-old (wo), 30-40 wo, and 61-70 wo endothelial Sirtuin 1-deleted (Sirt1(endo-/-)) mice and their corresponding knockout controls (Sirt1(Flox/Flox)). After 30-40 wk, Sirt1(endo-/-) animals exhibited diastolic dysfunction (DD), decreased mRNA expression of Serca2a in the LV, and decreased capillary density compared with control animals despite a similar VEGFa mRNA expression. However, LV fibrosis and hypoxia-inducible factor (HIF)1? expression were not different. The creation of a transverse aortic constriction (TAC) provoked more severe DD and LV fibrosis in Sirt1(endo-/-) compared with control TAC animals. Although the VEGFa mRNA expression was not different and the protein expression of HIF1? was higher in the Sirt1(endo-/-) TAC animals, capillary density remained reduced. In cultured endothelial cells administration of Sirtuin 1 inhibitor decreased mRNA expression of VEGF receptors FLT 1 and FLK 1. Ex vivo capillary sprouting from aortic explants showed impaired angiogenic response to VEGF in the Sirt1(endo-/-) mice. In conclusion, the data demonstrate 1) a defect in angiogenesis preceding development of DD; 2) dispensability of endothelial Sirtuin 1 under unstressed conditions and during normal aging; and 3) impaired angiogenic adaptation and aggravated DD in Sirt1(endo-/-) mice challenged with LV overload. Twit Text FOAVip Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction ????Am J Physiol Heart Circ Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25239805 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25239805 #FOAvip English Wikipedia <ref>{{Cite pmid|25239805 }}</ref> Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction #MMPMID25239805 Maizel J ; Xavier S ; Chen J ; Lin CH ; Vasko R ; Goligorsky MS Am J Physiol Heart Circ Physiol 2014[Dec]; 307 (12 ): H1691-704 PMID25239805 show ga Discordant myocardial growth and angiogenesis can explain left ventricular (LV) hypertrophy progressing toward heart failure with aging. Sirtuin 1 expression declines with age; therefore we explored the role played by angiogenesis and Sirtuin 1 in the development of cardiomyopathy. We compared the cardiac function of 10- to 15-wk-old (wo), 30-40 wo, and 61-70 wo endothelial Sirtuin 1-deleted (Sirt1(endo-/-)) mice and their corresponding knockout controls (Sirt1(Flox/Flox)). After 30-40 wk, Sirt1(endo-/-) animals exhibited diastolic dysfunction (DD), decreased mRNA expression of Serca2a in the LV, and decreased capillary density compared with control animals despite a similar VEGFa mRNA expression. However, LV fibrosis and hypoxia-inducible factor (HIF)1? expression were not different. The creation of a transverse aortic constriction (TAC) provoked more severe DD and LV fibrosis in Sirt1(endo-/-) compared with control TAC animals. Although the VEGFa mRNA expression was not different and the protein expression of HIF1? was higher in the Sirt1(endo-/-) TAC animals, capillary density remained reduced. In cultured endothelial cells administration of Sirtuin 1 inhibitor decreased mRNA expression of VEGF receptors FLT 1 and FLK 1. Ex vivo capillary sprouting from aortic explants showed impaired angiogenic response to VEGF in the Sirt1(endo-/-) mice. In conclusion, the data demonstrate 1) a defect in angiogenesis preceding development of DD; 2) dispensability of endothelial Sirtuin 1 under unstressed conditions and during normal aging; and 3) impaired angiogenic adaptation and aggravated DD in Sirt1(endo-/-) mice challenged with LV overload. |*Diastole [MESH] |*Neovascularization, Physiologic [MESH] |*Ventricular Function [MESH] |Age Factors [MESH] |Animals [MESH] |Cardiomegaly/*metabolism [MESH] |Coronary Vessels/growth & development/metabolism/physiology [MESH] |Endothelium, Vascular/*metabolism [MESH] |Fibrosis/metabolism [MESH] |Heart Ventricles/growth & development/metabolism/pathology [MESH] |Human Umbilical Vein Endothelial Cells/metabolism [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/genetics/metabolism [MESH] |Mice [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Receptors, Vascular Endothelial Growth Factor/genetics/metabolism [MESH] |Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics/metabolism [MESH] |Sirtuin 1/genetics/*metabolism [MESH]Sirtuin 1 ablation in endothelial cells is associated with impaired an(epmc).pdf DeepDyve Pubget Overpricing