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10.1152/ajpregu.00371.2014 http://scihub22266oqcxt.onion/10.1152/ajpregu.00371.2014 C4269673!4269673 !25339682     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25339682 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Regul+Integr+Comp+Physiol 2014 ; 307 (12 ): R1488-92 Nephropedia Template TP {{tp|p=25339682 |t=2014. Effects of chronic kidney disease on liver transport: quantitative intravital microscopy of fluorescein transport in the rat liver |pdf=|usr=}}{{25339682 }} gab.com Text Effects of chronic kidney disease on liver transport: quantitative intravital microscopy of fluorescein transport in the rat liver JO: Am J Physiol Regul Integr Comp Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25339682 #FOAvip Clinical studies indicate that hepatic drug transport may be altered in chronic kidney disease (CKD). Uremic solutes associated with CKD have been found to alter the expression and/or activity of hepatocyte transporters in experimental animals and in cultured cells. However, given the complexity and adaptability of hepatic transport, it is not clear whether these changes translate into significant alterations in hepatic transport in vivo. To directly measure the effect of CKD on hepatocyte transport in vivo, we conducted quantitative intravital microscopy of transport of the fluorescent organic anion fluorescein in the livers of rats following 5/6th nephrectomy, an established model of CKD. Our quantitative analysis of fluorescein transport showed that the rate of hepatocyte uptake was reduced by ?20% in 5/6th nephrectomized rats, consistent with previous observations of Oatp downregulation. However, the overall rate of transport into bile canaliculi was unaffected, suggesting compensatory changes in Mrp2-mediated secretion. Our study suggests that uremia resulting from 5/6th nephrectomy does not significantly impact the overall hepatic clearance of an Oatp substrate. Twit Text FOAVip Effects of chronic kidney disease on liver transport: quantitative intravital microscopy of fluorescein transport in the rat liver ????Am J Physiol Regul Integr Comp Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25339682 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25339682 #FOAvip English Wikipedia <ref>{{Cite pmid|25339682 }}</ref> Effects of chronic kidney disease on liver transport: quantitative intravital microscopy of fluorescein transport in the rat liver #MMPMID25339682 Ryan JC ; Dunn KW ; Decker BS Am J Physiol Regul Integr Comp Physiol 2014[Dec]; 307 (12 ): R1488-92 PMID25339682 show ga Clinical studies indicate that hepatic drug transport may be altered in chronic kidney disease (CKD). Uremic solutes associated with CKD have been found to alter the expression and/or activity of hepatocyte transporters in experimental animals and in cultured cells. However, given the complexity and adaptability of hepatic transport, it is not clear whether these changes translate into significant alterations in hepatic transport in vivo. To directly measure the effect of CKD on hepatocyte transport in vivo, we conducted quantitative intravital microscopy of transport of the fluorescent organic anion fluorescein in the livers of rats following 5/6th nephrectomy, an established model of CKD. Our quantitative analysis of fluorescein transport showed that the rate of hepatocyte uptake was reduced by ?20% in 5/6th nephrectomized rats, consistent with previous observations of Oatp downregulation. However, the overall rate of transport into bile canaliculi was unaffected, suggesting compensatory changes in Mrp2-mediated secretion. Our study suggests that uremia resulting from 5/6th nephrectomy does not significantly impact the overall hepatic clearance of an Oatp substrate. |ATP-Binding Cassette Transporters/metabolism [MESH] |Animals [MESH] |Bile Ducts/metabolism [MESH] |Biological Transport [MESH] |Disease Models, Animal [MESH] |Down-Regulation [MESH] |Fluorescein/administration & dosage/*metabolism [MESH] |Fluorescent Dyes/administration & dosage/*metabolism [MESH] |Hepatocytes/*metabolism [MESH] |Injections [MESH] |Liver/*metabolism [MESH] |Male [MESH] |Microscopy, Fluorescence, Multiphoton [MESH] |Nephrectomy [MESH] |Organic Anion Transporters/metabolism [MESH] |Rats, Sprague-Dawley [MESH] |Renal Insufficiency, Chronic/etiology/*metabolism [MESH]Effects of chronic kidney disease on liver transport: quantitative int(epmc).pdf DeepDyve Pubget Overpricing