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2014 ; 34
(7
): 724-31
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Effect of biocompatible peritoneal dialysis solution on residual renal function:
a systematic review of randomized controlled trials
#MMPMID25185015
Seo EY
; An SH
; Cho JH
; Suh HS
; Park SH
; Gwak H
; Kim YL
; Ha H
Perit Dial Int
2014[Nov]; 34
(7
): 724-31
PMID25185015
show ga
INTRODUCTION: Residual renal function (RRF) plays an important role in outcome of
peritoneal dialysis (PD) including mortality. It is, therefore, important to
provide a strategy for the preservation of RRF. The objective of this study was
to evaluate relative protective effects of new glucose-based multicompartmental
PD solution (PDS), which is well known to be more biocompatible than
glucose-based conventional PDS, on RRF compared to conventional PDS by performing
a systematic review (SR) of randomized controlled trials. METHODS: We searched
studies presented up to January 2014 in MEDLINE, EMBASE, the COCHRANE library,
and local databases. Three independent reviewers reviewed and extracted
prespecified data from each study. The random effects model, a more conservative
analysis model, was used to combine trials and to perform stratified analyses
based on the duration of follow-up. Study quality was assessed using the Cochrane
Handbook for risk of bias. Eleven articles with 1,034 patients were identified
for the SR. RESULTS: The heterogeneity of the studies under 12 months was very
high, and the heterogeneity decreased substantially when we stratified studies by
the duration of follow-up. The mean difference of the studies after 12 months was
0.46 mL/min/1.73 m(2) (95% confidence interval = 0.25 to + 0.67). CONCLUSION: New
PDS showed the effect to preserve and improve RRF for long-term use compared to
conventional PDS, even though it did not show a significant difference to
preserve RRF for short-term use.
free
free
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