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10.1038/ncomms6762 http://scihub22266oqcxt.onion/10.1038/ncomms6762 C4269169!4269169!25503194     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2014 ; 5 (ä): 5762 Nephropedia Template TP {{tp|p=25503194|t=2014. THE CDC13-STN1-TEN1 COMPLEX STIMULATES POL ? ACTIVITY BY PROMOTING RNA PRIMING AND PRIMASE-TO-POLYMERASE SWITCH |pdf=|usr=}}{{25503194}} gab.com Text THE CDC13-STN1-TEN1 COMPLEX STIMULATES POL ACTIVITY BY PROMOTING RNA PRIMING AND PRIMASE-TO-POLYMERASE SWITCH JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25503194 #FOAvip Emerging evidence suggests that Cdc13-Stn1-Ten1 (CST), an RPA-like ssDNA-binding complex, may regulate primase-Pol ? (PP) activity at telomeres constitutively, and at other genomic locations under conditions of replication stress. Here we examine the mechanisms of PP stimulation by CST using purified complexes derived from Candida glabrata. While CST does not enhance isolated DNA polymerase activity, it substantially augments both primase activity and primase-to-polymerase switching. CST also simultaneously shortens the RNA and lengthens the DNA in the chimeric products. Stn1, the most conserved subunit of CST, is alone capable of PP stimulation. Both the N-terminal OB fold and the C-terminal winged-helix domains of Stn1 can bind to the Pol12 subunit of the PP complex, and stimulate PP activity. Our findings provide mechanistic insights on a well-conserved pathway of PP regulation that is critical for genome stability. Twit Text FOAVip THE CDC13-STN1-TEN1 COMPLEX STIMULATES POL ACTIVITY BY PROMOTING RNA PRIMING AND PRIMASE-TO-POLYMERASE SWITCH ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25503194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25503194 #FOAvip English Wikipedia <ref>{{Cite pmid|25503194}}</ref> THE CDC13-STN1-TEN1 COMPLEX STIMULATES POL ? ACTIVITY BY PROMOTING RNA PRIMING AND PRIMASE-TO-POLYMERASE SWITCH #MMPMID25503194 Lue NF; Chan J; Wright WE; Hurwitz J Nat Commun 2014[]; 5 (ä): 5762 PMID25503194show ga Emerging evidence suggests that Cdc13-Stn1-Ten1 (CST), an RPA-like ssDNA-binding complex, may regulate primase-Pol ? (PP) activity at telomeres constitutively, and at other genomic locations under conditions of replication stress. Here we examine the mechanisms of PP stimulation by CST using purified complexes derived from Candida glabrata. While CST does not enhance isolated DNA polymerase activity, it substantially augments both primase activity and primase-to-polymerase switching. CST also simultaneously shortens the RNA and lengthens the DNA in the chimeric products. Stn1, the most conserved subunit of CST, is alone capable of PP stimulation. Both the N-terminal OB fold and the C-terminal winged-helix domains of Stn1 can bind to the Pol12 subunit of the PP complex, and stimulate PP activity. Our findings provide mechanistic insights on a well-conserved pathway of PP regulation that is critical for genome stability. äTHE CDC13-STN1-TEN1 COMPLEX STIMULATES POL ? ACTIVITY BY PROMOTING RNA(epmc).pdf DeepDyve Pubget Overpricing