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10.1016/j.clinthera.2014.09.023 http://scihub22266oqcxt.onion/10.1016/j.clinthera.2014.09.023 C4268345!4268345!25450475     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Ther 2014 ; 36 (12): 1873-81 Nephropedia Template TP {{tp|p=25450475|t=2014. New Approaches for Managing Preeclampsia: Clues from Clinical and Basic Research |pdf=|usr=}}{{25450475}} gab.com Text New Approaches for Managing Preeclampsia: Clues from Clinical and Basic Research JO: Clin Ther http://www.kidney.de/pget.php?&tw=1&pmid=25450475 #FOAvip One of the most common, and most vexing, obstetrical complications is preeclampsia-a major cause of maternal and perinatal morbidity. Hallmarked by new-onset hypertension and a myriad of other symptoms, the underlying cause of the disorder remain obscure, despite intensive research into the etiology. While the initiating events aren?t clear, one common finding in preeclampsia cases is failure of the maternal arteries which supply the placenta, with resulting hypoxia/ischemia. Intensive research over the last two decades has identified several categories of molecular dysfunction resulting from placental hypoxia, which when released into the maternal circulation are responsible for the spectrum of symptoms seen in these patient; in particular angiogenic imbalance and activation of innate and adaptive immune responses. Despite these new insights, little in the way of new treatments have been advanced into clinical practice for the management of these patients. Indeed, little in the way of therapeutic options exist for the obstetrician facing a preeclampsia case. Pharmacological management is typically to seizure prophylaxis and anti-hypertensives in severe cases to try and control the worsening hypertension. Ultimately, induction of labor is indicated; making preeclampsia a leading cause of premature birth. Here, the molecular mechanisms linking placental ischemia to the maternal symptoms of preeclampsia are reviewed, and several areas of recent research suggesting new potential therapeutic approaches for the management of preeclampsia are identified. Twit Text FOAVip New Approaches for Managing Preeclampsia: Clues from Clinical and Basic Research ????Clin Ther http://www.kidney.de/pget.php?&tw=1&pmid=25450475 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25450475 #FOAvip English Wikipedia <ref>{{Cite pmid|25450475}}</ref> New Approaches for Managing Preeclampsia: Clues from Clinical and Basic Research #MMPMID25450475 George E Clin Ther 2014[Dec]; 36 (12): 1873-81 PMID25450475show ga One of the most common, and most vexing, obstetrical complications is preeclampsia-a major cause of maternal and perinatal morbidity. Hallmarked by new-onset hypertension and a myriad of other symptoms, the underlying cause of the disorder remain obscure, despite intensive research into the etiology. While the initiating events aren?t clear, one common finding in preeclampsia cases is failure of the maternal arteries which supply the placenta, with resulting hypoxia/ischemia. Intensive research over the last two decades has identified several categories of molecular dysfunction resulting from placental hypoxia, which when released into the maternal circulation are responsible for the spectrum of symptoms seen in these patient; in particular angiogenic imbalance and activation of innate and adaptive immune responses. Despite these new insights, little in the way of new treatments have been advanced into clinical practice for the management of these patients. Indeed, little in the way of therapeutic options exist for the obstetrician facing a preeclampsia case. Pharmacological management is typically to seizure prophylaxis and anti-hypertensives in severe cases to try and control the worsening hypertension. Ultimately, induction of labor is indicated; making preeclampsia a leading cause of premature birth. Here, the molecular mechanisms linking placental ischemia to the maternal symptoms of preeclampsia are reviewed, and several areas of recent research suggesting new potential therapeutic approaches for the management of preeclampsia are identified. äNew Approaches for Managing Preeclampsia: Clues from Clinical and Basi(epmc).pdf DeepDyve Pubget Overpricing