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10.1016/j.ijdevneu.2014.07.008 http://scihub22266oqcxt.onion/10.1016/j.ijdevneu.2014.07.008 C4268161!4268161 !25107645     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25107645 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Dev+Neurosci 2014 ; 38 (ä): 59-67 Nephropedia Template TP {{tp|p=25107645 |t=2014. IUGR disrupts the PPAR?-Setd8-H4K20me(1) and Wnt signaling pathways in the juvenile rat hippocampus |pdf=|usr=}}{{25107645 }} gab.com Text IUGR disrupts the PPAR -Setd8-H4K20me(1) and Wnt signaling pathways in the juvenile rat hippocampus JO: Int J Dev Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25107645 #FOAvip Intrauterine growth restriction (IUGR) programs neurodevelopmental impairment and long-term neurological morbidities. Neurological morbidities in IUGR infants are correlated with changes hippocampal volume. We previously demonstrated that IUGR alters hippocampal cellular composition in both neonatal and juvenile rat pups in association with altered hippocampal gene expression and epigenetic determinants. PPAR? signaling is important for neurodevelopment as well as epigenetic integrity in the brain via the PPAR?-Setd8-H4K20me(1) axis and Wnt signaling. We hypothesized that IUGR would decrease expression of PPAR?, Setd8, and H4K20me(1) in juvenile rat hippocampus. We further hypothesized that reduced PPAR?-Setd8-H4K20me(1) would be associated with reduced Wnt signaling genes Wnt3a and ?-catenin, and wnt target gene Axin2. To test our hypothesis we used a rat model of uteroplacental insufficiency-induced IUGR. We demonstrated that PPAR? localizes to oligodendrocytes, neurons and astrocytes within the juvenile rat hippocampus. We also demonstrated that IUGR reduces levels of PPAR?, Setd8 and H4K20me(1) in male and female juvenile rat hippocampus in conjunction with reduced Wnt signaling components in only male rats. We speculate that reduced PPAR? and Wnt signaling may contribute to altered hippocampal cellular composition which, in turn, may contribute to impaired neurodevelopment and subsequent neurocognitive impairment in IUGR offspring. Twit Text FOAVip IUGR disrupts the PPAR -Setd8-H4K20me(1) and Wnt signaling pathways in the juvenile rat hippocampus ????Int J Dev Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25107645 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25107645 #FOAvip English Wikipedia <ref>{{Cite pmid|25107645 }}</ref> IUGR disrupts the PPAR?-Setd8-H4K20me(1) and Wnt signaling pathways in the juvenile rat hippocampus #MMPMID25107645 Ke X ; Xing B ; Yu B ; Yu X ; Majnik A ; Cohen S ; Lane R ; Joss-Moore L Int J Dev Neurosci 2014[Nov]; 38 (ä): 59-67 PMID25107645 show ga Intrauterine growth restriction (IUGR) programs neurodevelopmental impairment and long-term neurological morbidities. Neurological morbidities in IUGR infants are correlated with changes hippocampal volume. We previously demonstrated that IUGR alters hippocampal cellular composition in both neonatal and juvenile rat pups in association with altered hippocampal gene expression and epigenetic determinants. PPAR? signaling is important for neurodevelopment as well as epigenetic integrity in the brain via the PPAR?-Setd8-H4K20me(1) axis and Wnt signaling. We hypothesized that IUGR would decrease expression of PPAR?, Setd8, and H4K20me(1) in juvenile rat hippocampus. We further hypothesized that reduced PPAR?-Setd8-H4K20me(1) would be associated with reduced Wnt signaling genes Wnt3a and ?-catenin, and wnt target gene Axin2. To test our hypothesis we used a rat model of uteroplacental insufficiency-induced IUGR. We demonstrated that PPAR? localizes to oligodendrocytes, neurons and astrocytes within the juvenile rat hippocampus. We also demonstrated that IUGR reduces levels of PPAR?, Setd8 and H4K20me(1) in male and female juvenile rat hippocampus in conjunction with reduced Wnt signaling components in only male rats. We speculate that reduced PPAR? and Wnt signaling may contribute to altered hippocampal cellular composition which, in turn, may contribute to impaired neurodevelopment and subsequent neurocognitive impairment in IUGR offspring. |Actins/genetics/metabolism [MESH] |Animals [MESH] |Animals, Newborn [MESH] |Body Weight [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Fetal Growth Retardation/*pathology [MESH] |Gene Expression Regulation, Developmental/*physiology [MESH] |Hippocampus/*metabolism/*physiopathology [MESH] |Histone-Lysine N-Methyltransferase/genetics/metabolism [MESH] |Histones/metabolism [MESH] |Male [MESH] |PPAR gamma/genetics/*metabolism [MESH] |Phosphopyruvate Hydratase/metabolism [MESH] |RNA, Messenger [MESH] |Rats [MESH] |Sex Factors [MESH]IUGR disrupts the PPAR?-Setd8-H4K20me(1) and Wnt signaling pathways in(epmc).pdf DeepDyve Pubget Overpricing