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10.1038/jid.2014.289 http://scihub22266oqcxt.onion/10.1038/jid.2014.289 C4268113!4268113!25007044     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Invest+Dermatol 2015 ; 135 (1): 84-93 Nephropedia Template TP {{tp|p=25007044|t=2015. The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy |pdf=|usr=}}{{25007044}} gab.com Text The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy JO: J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=25007044 #FOAvip Site-specific differences in skin response to pathogens and in the course of cutaneous inflammatory diseases are well appreciated. The composition and localization of cutaneous leukocytes has been studied extensively using histology and flow cytometry. However, the precise three-dimensional (3D) distribution of distinct immune cell subsets within skin at different body sites requires visualization of intact living skin. We used intravital multiphoton microscopy in transgenic reporter mice in combination with quantitative flow cytometry to generate a 3D immune cell atlas of mouse skin. The 3D location of innate and adaptive immune cells and site-specific differences in the densities of macrophages, T cells and mast cells at four defined sites (ear, back, footpad, tail) is presented. The combinatorial approach further demonstrates an as yet unreported age-dependent expansion of dermal gamma-delta T cells. Localization of dermal immune cells relative to anatomical structures was also determined. While dendritic cells were dispersed homogeneously within the dermis, mast cells preferentially localized to the perivascular space. Finally, we show the functional relevance of site-specific mast cell disparities using the passive cutaneous anaphylaxis model. These approaches are applicable to assessing immune cell variations and potential functional consequences in the setting of infection as well as the pathogenesis of inflammatory skin conditions. Twit Text FOAVip The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy ????J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=25007044 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25007044 #FOAvip English Wikipedia <ref>{{Cite pmid|25007044}}</ref> The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy #MMPMID25007044 Tong PL; Roediger B; Kolesnikoff N; Biro M; Tay SS; Jain R; Shaw LE; Grimbaldeston MA; Weninger W J Invest Dermatol 2015[Jan]; 135 (1): 84-93 PMID25007044show ga Site-specific differences in skin response to pathogens and in the course of cutaneous inflammatory diseases are well appreciated. The composition and localization of cutaneous leukocytes has been studied extensively using histology and flow cytometry. However, the precise three-dimensional (3D) distribution of distinct immune cell subsets within skin at different body sites requires visualization of intact living skin. We used intravital multiphoton microscopy in transgenic reporter mice in combination with quantitative flow cytometry to generate a 3D immune cell atlas of mouse skin. The 3D location of innate and adaptive immune cells and site-specific differences in the densities of macrophages, T cells and mast cells at four defined sites (ear, back, footpad, tail) is presented. The combinatorial approach further demonstrates an as yet unreported age-dependent expansion of dermal gamma-delta T cells. Localization of dermal immune cells relative to anatomical structures was also determined. While dendritic cells were dispersed homogeneously within the dermis, mast cells preferentially localized to the perivascular space. Finally, we show the functional relevance of site-specific mast cell disparities using the passive cutaneous anaphylaxis model. These approaches are applicable to assessing immune cell variations and potential functional consequences in the setting of infection as well as the pathogenesis of inflammatory skin conditions. äThe skin immune atlas: three-dimensional analysis of cutaneous leukocy(epmc).pdf DeepDyve Pubget Overpricing