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10.1038/onc.2014.172 http://scihub22266oqcxt.onion/10.1038/onc.2014.172 C4268091!4268091!24931168     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogene 2015 ; 34 (18): 2288-96 Nephropedia Template TP {{tp|p=24931168|t=2015. Epigenetic mechanisms of tumorigenicity manifesting in stem cells |pdf=|usr=}}{{24931168}} gab.com Text Epigenetic mechanisms of tumorigenicity manifesting in stem cells JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=24931168 #FOAvip One of the biggest roadblocks to using stem cells as the basis for regenerative medicine therapies is the tumorigenicity of stem cells. Unfortunately, the unique abilities of stem cells to self-renew and differentiate into a variety of cell types are also mechanistically linked to their tumorigenic behaviors. Understanding the mechanisms underlying the close relationship between stem cells and cancer cells has therefore become a primary goal in the field. In addition, knowledge gained from investigating the striking parallels between mechanisms orchestrating normal embryogenesis and those that invoke tumorigenesis may well serve as the foundation for developing novel cancer treatments. Emerging discoveries have demonstrated that epigenetic regulatory machinery plays important roles in normal stem cell functions, cancer development, and cancer stem cell identity. These studies provide valuable insights into both the shared and distinct mechanisms by which pluripotency and oncogenicity are established and regulated. In this review, the cancer-related epigenetic mechanisms found in pluripotent stem cells and cancer stem cells will be discussed, focusing on both the similarities and the differences. Twit Text FOAVip Epigenetic mechanisms of tumorigenicity manifesting in stem cells ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=24931168 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24931168 #FOAvip English Wikipedia <ref>{{Cite pmid|24931168}}</ref> Epigenetic mechanisms of tumorigenicity manifesting in stem cells #MMPMID24931168 Tung PY; Knoepfler PS Oncogene 2015[Apr]; 34 (18): 2288-96 PMID24931168show ga One of the biggest roadblocks to using stem cells as the basis for regenerative medicine therapies is the tumorigenicity of stem cells. Unfortunately, the unique abilities of stem cells to self-renew and differentiate into a variety of cell types are also mechanistically linked to their tumorigenic behaviors. Understanding the mechanisms underlying the close relationship between stem cells and cancer cells has therefore become a primary goal in the field. In addition, knowledge gained from investigating the striking parallels between mechanisms orchestrating normal embryogenesis and those that invoke tumorigenesis may well serve as the foundation for developing novel cancer treatments. Emerging discoveries have demonstrated that epigenetic regulatory machinery plays important roles in normal stem cell functions, cancer development, and cancer stem cell identity. These studies provide valuable insights into both the shared and distinct mechanisms by which pluripotency and oncogenicity are established and regulated. In this review, the cancer-related epigenetic mechanisms found in pluripotent stem cells and cancer stem cells will be discussed, focusing on both the similarities and the differences. äEpigenetic mechanisms of tumorigenicity manifesting in stem cells (epmc).pdf DeepDyve Pubget Overpricing