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10.1073/pnas.1412743111 http://scihub22266oqcxt.onion/10.1073/pnas.1412743111 C4267390!4267390!25422459     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25422459&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (49): 17420-5 Nephropedia Template TP {{tp|p=25422459|t=2014. Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA |pdf=|usr=}}{{25422459}} gab.com Text Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25422459 #FOAvip The essential U2AF65 protein recognizes a splice site signal that is frequently mutated in inherited human diseases. Herein we show that reduced U2AF65 binding is a molecular consequence of splice site mutations that commonly underlie human genetic disease. We demonstrate for a proof-of-principle case that structure-guided U2AF65 variants are a feasible tool to evoke disease-relevant changes in pre-mRNA splicing. Twit Text FOAVip Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25422459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25422459 #FOAvip English Wikipedia <ref>{{Cite pmid|25422459}}</ref> Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA #MMPMID25422459 Agrawal AA; McLaughlin KJ; Jenkins JL; Kielkopf CL Proc Natl Acad Sci U S A 2014[Dec]; 111 (49): 17420-5 PMID25422459show ga The essential U2AF65 protein recognizes a splice site signal that is frequently mutated in inherited human diseases. Herein we show that reduced U2AF65 binding is a molecular consequence of splice site mutations that commonly underlie human genetic disease. We demonstrate for a proof-of-principle case that structure-guided U2AF65 variants are a feasible tool to evoke disease-relevant changes in pre-mRNA splicing. äStructure-guided U2AF65 variant improves recognition and splicing of a(epmc).pdf DeepDyve Pubget Overpricing