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10.1073/pnas.1409700111 http://scihub22266oqcxt.onion/10.1073/pnas.1409700111 C4267378!4267378!25422452     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (49): 17582-7 Nephropedia Template TP {{tp|p=25422452|t=2014. Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation |pdf=|usr=}}{{25422452}} gab.com Text Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25422452 #FOAvip Tumor-associated macrophages are often associated with poor prognosis, but the molecular cues that impart the change in macrophage phenotypes are mostly unclear. Our findings identify c-Jun N-terminal phosphorylation as a key mediator of macrophage education and point to a recruitment of immunosuppressive regulatory T cells as a possible effector protumorigenic mechanism. This cross-talk between adaptive and innate immune responses occurs before overt tumorigenesis, reversing the classic paradigm of initiation and promotion. Our findings raise the possibility that targeting immune checkpoints could be effective for tumor prevention in chronic inflammatory diseases. Twit Text FOAVip Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25422452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25422452 #FOAvip English Wikipedia <ref>{{Cite pmid|25422452}}</ref> Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation #MMPMID25422452 Hefetz-Sela S; Stein I; Klieger Y; Porat R; Sade-Feldman M; Zreik F; Nagler A; Pappo O; Quagliata L; Dazert E; Eferl R; Terracciano L; Wagner EF; Ben-Neriah Y; Baniyash M; Pikarsky E Proc Natl Acad Sci U S A 2014[Dec]; 111 (49): 17582-7 PMID25422452show ga Tumor-associated macrophages are often associated with poor prognosis, but the molecular cues that impart the change in macrophage phenotypes are mostly unclear. Our findings identify c-Jun N-terminal phosphorylation as a key mediator of macrophage education and point to a recruitment of immunosuppressive regulatory T cells as a possible effector protumorigenic mechanism. This cross-talk between adaptive and innate immune responses occurs before overt tumorigenesis, reversing the classic paradigm of initiation and promotion. Our findings raise the possibility that targeting immune checkpoints could be effective for tumor prevention in chronic inflammatory diseases. äAcquisition of an immunosuppressive protumorigenic macrophage phenotyp(epmc).pdf DeepDyve Pubget Overpricing