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10.1073/pnas.1417686111 http://scihub22266oqcxt.onion/10.1073/pnas.1417686111 C4267361!4267361!25422436     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (49): 17528-33 Nephropedia Template TP {{tp|p=25422436|t=2014. A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton |pdf=|usr=}}{{25422436}} gab.com Text A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25422436 #FOAvip Cellular activities are regulated by signaling pathways in which information is transduced biochemically. Increasingly it is appreciated that regulation also involves mechanical signaling, where mechanical information is mechanotransduced into biochemical information. However, little is understood about the cooperation of mechanical and biochemical signaling in mixed pathways. We identified a pathway where the two types of signaling work in harmony to remodel actomyosin stress fibers in the cell?s cytoskeleton. We present evidence that expansion or contraction of fibers alters the actin filament overlap, a mechanical signal that is mechanotransduced into actin assembly or disassembly, which in turn alters the overlap. A mathematical model accurately describes our measurements and shows that this mechanical-biochemical feedback loop synchronizes actin remodeling with fiber length changes. Twit Text FOAVip A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25422436 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25422436 #FOAvip English Wikipedia <ref>{{Cite pmid|25422436}}</ref> A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton #MMPMID25422436 Stachowiak MR; Smith MA; Blankman E; Chapin LM; Balcioglu HE; Wang S; Beckerle MC; O'Shaughnessy B Proc Natl Acad Sci U S A 2014[Dec]; 111 (49): 17528-33 PMID25422436show ga Cellular activities are regulated by signaling pathways in which information is transduced biochemically. Increasingly it is appreciated that regulation also involves mechanical signaling, where mechanical information is mechanotransduced into biochemical information. However, little is understood about the cooperation of mechanical and biochemical signaling in mixed pathways. We identified a pathway where the two types of signaling work in harmony to remodel actomyosin stress fibers in the cell?s cytoskeleton. We present evidence that expansion or contraction of fibers alters the actin filament overlap, a mechanical signal that is mechanotransduced into actin assembly or disassembly, which in turn alters the overlap. A mathematical model accurately describes our measurements and shows that this mechanical-biochemical feedback loop synchronizes actin remodeling with fiber length changes. äA mechanical-biochemical feedback loop regulates remodeling in the act(epmc).pdf DeepDyve Pubget Overpricing