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10.1073/pnas.1420936111 http://scihub22266oqcxt.onion/10.1073/pnas.1420936111 C4267357!4267357!25422432     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (49): 17576-81 Nephropedia Template TP {{tp|p=25422432|t=2014. Molecular architecture of the ?? T cell receptor?CD3 complex |pdf=|usr=}}{{25422432}} gab.com Text Molecular architecture of the T cell receptor CD3 complex JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25422432 #FOAvip The T-cell receptor (TCR) does not signal on its own. Instead, it is constitutively associated with the CD3 coreceptors, which contain intracellular signaling motifs. Although antigen (Ag) recognition by the TCR and the activation of T cells after CD3 activation have been extensively studied, there is far less known about how the TCR relays the binding of Ag to initiate intracellular signaling. Detailed study of the eight-chain TCR?CD3 complex is hampered by limited structural information for how the components of the complex interact. We use complementary structural approaches to examine where the TCR?CD3 extracellular domains are placed relative to each other and the overall organization of the complex. Twit Text FOAVip Molecular architecture of the T cell receptor CD3 complex ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25422432 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25422432 #FOAvip English Wikipedia <ref>{{Cite pmid|25422432}}</ref> Molecular architecture of the ?? T cell receptor?CD3 complex #MMPMID25422432 Birnbaum ME; Berry R; Hsiao YS; Chen Z; Shingu-Vazquez MA; Yu X; Waghray D; Fischer S; McCluskey J; Rossjohn J; Walz T; Garcia KC Proc Natl Acad Sci U S A 2014[Dec]; 111 (49): 17576-81 PMID25422432show ga The T-cell receptor (TCR) does not signal on its own. Instead, it is constitutively associated with the CD3 coreceptors, which contain intracellular signaling motifs. Although antigen (Ag) recognition by the TCR and the activation of T cells after CD3 activation have been extensively studied, there is far less known about how the TCR relays the binding of Ag to initiate intracellular signaling. Detailed study of the eight-chain TCR?CD3 complex is hampered by limited structural information for how the components of the complex interact. We use complementary structural approaches to examine where the TCR?CD3 extracellular domains are placed relative to each other and the overall organization of the complex. äMolecular architecture of the ?? T cell receptor?CD3 complex (epmc).pdf DeepDyve Pubget Overpricing