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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (49): 17606-11 Nephropedia Template TP
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MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers #MMPMID25422431
Mohseni M; Cidado J; Croessmann S; Cravero K; Cimino-Mathews A; Wong HY; Scharpf R; Zabransky DJ; Abukhdeir AM; Garay JP; Wang GM; Beaver JA; Cochran RL; Blair BG; Rosen DM; Erlanger B; Argani P; Hurley PJ; Lauring J; Park BH
Proc Natl Acad Sci U S A 2014[Dec]; 111 (49): 17606-11 PMID25422431show ga
Despite the widespread use and success of tamoxifen for treating ER-positive breast cancers, overcoming resistance to this drug remains an unmet need in clinical breast oncology. The results presented in this study demonstrate that overexpression of a novel gene, MACROD2, can mediate tamoxifen resistance and estrogen independent growth in human breast cancers, and that amplification of MACROD2 in primary breast tumors is associated with worse overall survival.