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10.1073/pnas.1408650111 http://scihub22266oqcxt.onion/10.1073/pnas.1408650111 C4267353!4267353 !25422431     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25422431 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (49 ): 17606-11 Nephropedia Template TP {{tp|p=25422431 |t=2014. MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers |pdf=|usr=}}{{25422431 }} gab.com Text MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25422431 #FOAvip Tamoxifen is effective for treating estrogen receptor-alpha (ER) positive breast cancers. However, few molecular mediators of tamoxifen resistance have been elucidated. Here we describe a previously unidentified gene, MACROD2 that confers tamoxifen resistance and estrogen independent growth. We found MACROD2 is amplified and overexpressed in metastatic tamoxifen-resistant tumors. Transgene overexpression of MACROD2 in breast cancer cell lines results in tamoxifen resistance, whereas RNAi-mediated gene knock down reverses this phenotype. MACROD2 overexpression also leads to estrogen independent growth in xenograft assays. Mechanistically, MACROD2 increases p300 binding to estrogen response elements in a subset of ER regulated genes. Primary breast cancers and matched metastases demonstrate MACROD2 expression can change with disease evolution, and increased expression and amplification of MACROD2 in primary tumors is associated with worse overall survival. These studies establish MACROD2 as a key mediator of estrogen independent growth and tamoxifen resistance, as well as a potential novel target for diagnostics and therapy. Twit Text FOAVip MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25422431 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25422431 #FOAvip English Wikipedia <ref>{{Cite pmid|25422431 }}</ref> MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers #MMPMID25422431 Mohseni M ; Cidado J ; Croessmann S ; Cravero K ; Cimino-Mathews A ; Wong HY ; Scharpf R ; Zabransky DJ ; Abukhdeir AM ; Garay JP ; Wang GM ; Beaver JA ; Cochran RL ; Blair BG ; Rosen DM ; Erlanger B ; Argani P ; Hurley PJ ; Lauring J ; Park BH Proc Natl Acad Sci U S A 2014[Dec]; 111 (49 ): 17606-11 PMID25422431 show ga Tamoxifen is effective for treating estrogen receptor-alpha (ER) positive breast cancers. However, few molecular mediators of tamoxifen resistance have been elucidated. Here we describe a previously unidentified gene, MACROD2 that confers tamoxifen resistance and estrogen independent growth. We found MACROD2 is amplified and overexpressed in metastatic tamoxifen-resistant tumors. Transgene overexpression of MACROD2 in breast cancer cell lines results in tamoxifen resistance, whereas RNAi-mediated gene knock down reverses this phenotype. MACROD2 overexpression also leads to estrogen independent growth in xenograft assays. Mechanistically, MACROD2 increases p300 binding to estrogen response elements in a subset of ER regulated genes. Primary breast cancers and matched metastases demonstrate MACROD2 expression can change with disease evolution, and increased expression and amplification of MACROD2 in primary tumors is associated with worse overall survival. These studies establish MACROD2 as a key mediator of estrogen independent growth and tamoxifen resistance, as well as a potential novel target for diagnostics and therapy. |*Drug Resistance, Neoplasm [MESH] |Base Sequence [MESH] |Breast Neoplasms/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |DNA Repair Enzymes/*metabolism [MESH] |Epigenesis, Genetic [MESH] |Estrogens/*metabolism [MESH] |Female [MESH] |Gene Deletion [MESH] |Gene Dosage [MESH] |Humans [MESH] |Hydrolases/*metabolism [MESH] |Molecular Sequence Data [MESH] |Neoplasm Transplantation [MESH] |Phenotype [MESH] |Prognosis [MESH] |RNA Interference [MESH] |RNA, Small Interfering/metabolism [MESH] |Receptors, Estrogen/metabolism [MESH] |Tamoxifen/*pharmacology [MESH] |Transgenes [MESH]MACROD2 overexpression mediates estrogen independent growth and tamoxi(epmc).pdf DeepDyve Pubget Overpricing