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10.1084/jem.20141759 http://scihub22266oqcxt.onion/10.1084/jem.20141759 C4267241!4267241!25488983     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Exp+Med 2014 ; 211 (13): 2537-47 Nephropedia Template TP {{tp|p=25488983|t=2014. Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K |pdf=|usr=}}{{25488983}} gab.com Text Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=25488983 #FOAvip Lucas et al. identify humans with a gain-of-function mutation in PIK3R1, encoding the p85? subunit of PI3K. The splice site mutation causes in-frame skipping of exon 11, resulting in altered p85? association with p110? that stabilizes the catalytic subunit but fails to properly inhibit catalytic activity. The patients have immunodeficiency and lymphoproliferation with skewing of CD8+ T cells toward terminally differentiated and senescent effector cells that have shortened telomeres. Twit Text FOAVip Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=25488983 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25488983 #FOAvip English Wikipedia <ref>{{Cite pmid|25488983}}</ref> Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K #MMPMID25488983 Lucas CL; Zhang Y; Venida A; Wang Y; Hughes J; McElwee J; Butrick M; Matthews H; Price S; Biancalana M; Wang X; Richards M; Pozos T; Barlan I; Ozen A; Rao VK; Su HC; Lenardo MJ J Exp Med 2014[Dec]; 211 (13): 2537-47 PMID25488983show ga Lucas et al. identify humans with a gain-of-function mutation in PIK3R1, encoding the p85? subunit of PI3K. The splice site mutation causes in-frame skipping of exon 11, resulting in altered p85? association with p110? that stabilizes the catalytic subunit but fails to properly inhibit catalytic activity. The patients have immunodeficiency and lymphoproliferation with skewing of CD8+ T cells toward terminally differentiated and senescent effector cells that have shortened telomeres. äHeterozygous splice mutation in PIK3R1 causes human immunodeficiency w(epmc).pdf DeepDyve Pubget Overpricing