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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Exp+Med 2014 ; 211 (13): 2583-98 Nephropedia Template TP
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Control of lymphocyte egress from lymph nodes through ?2-adrenergic receptors #MMPMID25422496
Nakai A; Hayano Y; Furuta F; Noda M; Suzuki K
J Exp Med 2014[Dec]; 211 (13): 2583-98 PMID25422496show ga
Using pharmacological activation and genetic ablation of ?2-adrenergic receptors (?2ARs) in mice, Nakai et al. show that ?2ARs expressed on lymphocytes can regulate egress of these cells from lymph nodes, while altering the responsiveness of chemokine receptors CCR7 and CXCR4. They identify that ?2ARs can physically interact with these chemokine receptors. And, in mouse models of T cell?mediated inflammation, ?2AR-mediated signals are shown to inhibit trafficking of antigen-primed T cells, reducing their numbers in inflamed peripheral tissues.