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10.1084/jem.20140455

http://scihub22266oqcxt.onion/10.1084/jem.20140455
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C4267237!4267237!25403443
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suck abstract from ncbi


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pmid25403443      J+Exp+Med 2014 ; 211 (13): 2519-35
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  • CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation #MMPMID25403443
  • Kennedy JM; Fodil N; Torre S; Bongfen SE; Olivier JF; Leung V; Langlais D; Meunier C; Berghout J; Langat P; Schwartzentruber J; Majewski J; Lathrop M; Vidal SM; Gros P
  • J Exp Med 2014[Dec]; 211 (13): 2519-35 PMID25403443show ga
  • Kennedy et al. identify a mutation in coiled-coil domain containing protein 88b (Ccdc88b) that confers protection against lethal neuroinflammation during experimental cerebral malaria. CCDC88B is expressed in immune cells and regulates T cell maturation and effector functions. In humans, the CCDC88B gene maps to a locus associated with susceptibility to several inflammatory and autoimmune disorders.
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