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10.1084/jem.20140455 http://scihub22266oqcxt.onion/10.1084/jem.20140455 C4267237!4267237 !25403443     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25403443 &cmd=llinks): Failed to open stream: HTTP request failed! 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CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation |pdf=|usr=}}{{25403443 }} gab.com Text CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=25403443 #FOAvip We used a genome-wide screen in mutagenized mice to identify genes which inactivation protects against lethal neuroinflammation during experimental cerebral malaria (ECM). We identified an ECM-protective mutation in coiled-coil domain containing protein 88b (Ccdc88b), a poorly annotated gene that is found expressed specifically in spleen, bone marrow, lymph nodes, and thymus. The CCDC88B protein is abundantly expressed in immune cells, including both CD4(+) and CD8(+) T lymphocytes, and in myeloid cells, and loss of CCDC88B protein expression has pleiotropic effects on T lymphocyte functions, including impaired maturation in vivo, significantly reduced activation, reduced cell division as well as impaired cytokine production (IFN-? and TNF) in response to T cell receptor engagement, or to nonspecific stimuli in vitro, and during the course of P. berghei infection in vivo. This identifies CCDC88B as a novel and important regulator of T cell function. The human CCDC88B gene maps to the 11q13 locus that is associated with susceptibility to several inflammatory and auto-immune disorders. Our findings strongly suggest that CCDC88B is the morbid gene underlying the pleiotropic effect of the 11q13 locus on inflammation. Twit Text FOAVip CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=25403443 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25403443 #FOAvip English Wikipedia <ref>{{Cite pmid|25403443 }}</ref> CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation #MMPMID25403443 Kennedy JM ; Fodil N ; Torre S ; Bongfen SE ; Olivier JF ; Leung V ; Langlais D ; Meunier C ; Berghout J ; Langat P ; Schwartzentruber J ; Majewski J ; Lathrop M ; Vidal SM ; Gros P J Exp Med 2014[Dec]; 211 (13 ): 2519-35 PMID25403443 show ga We used a genome-wide screen in mutagenized mice to identify genes which inactivation protects against lethal neuroinflammation during experimental cerebral malaria (ECM). We identified an ECM-protective mutation in coiled-coil domain containing protein 88b (Ccdc88b), a poorly annotated gene that is found expressed specifically in spleen, bone marrow, lymph nodes, and thymus. The CCDC88B protein is abundantly expressed in immune cells, including both CD4(+) and CD8(+) T lymphocytes, and in myeloid cells, and loss of CCDC88B protein expression has pleiotropic effects on T lymphocyte functions, including impaired maturation in vivo, significantly reduced activation, reduced cell division as well as impaired cytokine production (IFN-? and TNF) in response to T cell receptor engagement, or to nonspecific stimuli in vitro, and during the course of P. berghei infection in vivo. This identifies CCDC88B as a novel and important regulator of T cell function. The human CCDC88B gene maps to the 11q13 locus that is associated with susceptibility to several inflammatory and auto-immune disorders. Our findings strongly suggest that CCDC88B is the morbid gene underlying the pleiotropic effect of the 11q13 locus on inflammation. |*Cell Differentiation [MESH] |Animals [MESH] |Base Sequence [MESH] |Carrier Proteins/*genetics/metabolism [MESH] |Chromosomes, Human, Pair 11/genetics [MESH] |Disease Resistance/immunology [MESH] |Ethylnitrosourea [MESH] |Female [MESH] |Gene Expression Regulation [MESH] |Genetic Association Studies [MESH] |Hematopoietic System/metabolism [MESH] |Humans [MESH] |Inflammation/*immunology/*pathology [MESH] |Lymphocyte Activation/immunology [MESH] |Malaria, Cerebral/genetics/immunology/parasitology/prevention & control [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Mice, Mutant Strains [MESH] |Molecular Sequence Data [MESH] |Mutation/genetics [MESH] |Myeloid Cells/metabolism [MESH] |Organ Specificity/genetics [MESH] |Plasmodium berghei [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Receptors, Antigen, T-Cell/metabolism [MESH]CCDC88B is a novel regulator of maturation and effector functions of T(epmc).pdf DeepDyve Pubget Overpricing