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10.1084/jem.20141307

http://scihub22266oqcxt.onion/10.1084/jem.20141307
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C4267229!4267229!25422492
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suck abstract from ncbi


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pmid25422492      J+Exp+Med 2014 ; 211 (13): 2549-66
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  • DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity #MMPMID25422492
  • Zhang Q; Dove CG; Hor JL; Murdock HM; Strauss-Albee DM; Garcia JA; Mandl JN; Grodick RA; Jing H; Chandler-Brown DB; Lenardo TE; Crawford G; Matthews HF; Freeman AF; Cornall RJ; Germain RN; Mueller SN; Su HC
  • J Exp Med 2014[Dec]; 211 (13): 2549-66 PMID25422492show ga
  • Zhang et al. show that DOCK8-deficient T and NK cells develop cell and nuclear shape abnormalities that do not impair chemotaxis but contribute to a form of cell death they term cytothripsis. Cytothripsis of DOCK8-deficient cells prevents the generation of long-lived skin-resident memory CD8 T cells resulting in impaired immune response to skin infection.
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