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10.1101/gad.251371.114 http://scihub22266oqcxt.onion/10.1101/gad.251371.114 C4265679!4265679 !25512563     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25512563 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25512563 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2014 ; 28 (24 ): 2764-77 Nephropedia Template TP {{tp|p=25512563 |t=2014. ?-Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo |pdf=|usr=}}{{25512563 }} gab.com Text -Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25512563 #FOAvip Collective epithelial migration is important throughout embryonic development. The underlying mechanisms are poorly understood but likely involve spatially localized activation of Rho GTPases. We previously reported that Rac1 is essential for generating the protrusive activity that drives the collective migration of anterior visceral endoderm (AVE) cells in the early mouse embryo. To identify potential regulators of Rac1, we first performed an RNAi screen of Rho family exchange factors (guanine nucleotide exchange factor [GEF]) in an in vitro collective epithelial migration assay and identified ?-Pix. Genetic deletion of ?-Pix in mice disrupts collective AVE migration, while high-resolution live imaging revealed that this is associated with randomly directed protrusive activity. We conclude that ?-Pix controls the spatial localization of Rac1 activity to drive collective AVE migration at a critical stage in mouse development. Twit Text FOAVip -Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25512563 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25512563 #FOAvip English Wikipedia <ref>{{Cite pmid|25512563 }}</ref> ?-Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo #MMPMID25512563 Omelchenko T ; Rabadan MA ; Hernández-Martínez R ; Grego-Bessa J ; Anderson KV ; Hall A Genes Dev 2014[Dec]; 28 (24 ): 2764-77 PMID25512563 show ga Collective epithelial migration is important throughout embryonic development. The underlying mechanisms are poorly understood but likely involve spatially localized activation of Rho GTPases. We previously reported that Rac1 is essential for generating the protrusive activity that drives the collective migration of anterior visceral endoderm (AVE) cells in the early mouse embryo. To identify potential regulators of Rac1, we first performed an RNAi screen of Rho family exchange factors (guanine nucleotide exchange factor [GEF]) in an in vitro collective epithelial migration assay and identified ?-Pix. Genetic deletion of ?-Pix in mice disrupts collective AVE migration, while high-resolution live imaging revealed that this is associated with randomly directed protrusive activity. We conclude that ?-Pix controls the spatial localization of Rac1 activity to drive collective AVE migration at a critical stage in mouse development. |Animals [MESH] |Cell Movement/genetics [MESH] |Embryo, Mammalian [MESH] |Endoderm/*cytology [MESH] |Epithelial Cells/cytology [MESH] |Gene Deletion [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Neuropeptides/genetics/metabolism [MESH] |Protein Transport/genetics [MESH] |Rho Guanine Nucleotide Exchange Factors/genetics/*metabolism [MESH] |Viscera/cytology [MESH]?-Pix directs collective migration of anterior visceral endoderm cells(epmc).pdf DeepDyve Pubget Overpricing