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10.1101/gad.249730.114 http://scihub22266oqcxt.onion/10.1101/gad.249730.114 C4265678!4265678 !25512562     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25512562 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2014 ; 28 (24 ): 2750-63 Nephropedia Template TP {{tp|p=25512562 |t=2014. Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire |pdf=|usr=}}{{25512562 }} gab.com Text Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25512562 #FOAvip KAT6 histone acetyltransferases (HATs) are highly conserved in eukaryotes and have been shown to play important roles in transcriptional regulation. Here, we demonstrate that the Drosophila KAT6 Enok acetylates histone H3 Lys 23 (H3K23) in vitro and in vivo. Mutants lacking functional Enok exhibited defects in the localization of Oskar (Osk) to the posterior end of the oocyte, resulting in loss of germline formation and abdominal segments in the embryo. RNA sequencing (RNA-seq) analysis revealed that spire (spir) and maelstrom (mael), both required for the posterior localization of Osk in the oocyte, were down-regulated in enok mutants. Chromatin immunoprecipitation showed that Enok is localized to and acetylates H3K23 at the spir and mael genes. Furthermore, Gal4-driven expression of spir in the germline can largely rescue the defective Osk localization in enok mutant ovaries. Our results suggest that the Enok-mediated H3K23 acetylation (H3K23Ac) promotes the expression of spir, providing a specific mechanism linking oocyte polarization to histone modification. Twit Text FOAVip Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25512562 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25512562 #FOAvip English Wikipedia <ref>{{Cite pmid|25512562 }}</ref> Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire #MMPMID25512562 Huang F ; Paulson A ; Dutta A ; Venkatesh S ; Smolle M ; Abmayr SM ; Workman JL Genes Dev 2014[Dec]; 28 (24 ): 2750-63 PMID25512562 show ga KAT6 histone acetyltransferases (HATs) are highly conserved in eukaryotes and have been shown to play important roles in transcriptional regulation. Here, we demonstrate that the Drosophila KAT6 Enok acetylates histone H3 Lys 23 (H3K23) in vitro and in vivo. Mutants lacking functional Enok exhibited defects in the localization of Oskar (Osk) to the posterior end of the oocyte, resulting in loss of germline formation and abdominal segments in the embryo. RNA sequencing (RNA-seq) analysis revealed that spire (spir) and maelstrom (mael), both required for the posterior localization of Osk in the oocyte, were down-regulated in enok mutants. Chromatin immunoprecipitation showed that Enok is localized to and acetylates H3K23 at the spir and mael genes. Furthermore, Gal4-driven expression of spir in the germline can largely rescue the defective Osk localization in enok mutant ovaries. Our results suggest that the Enok-mediated H3K23 acetylation (H3K23Ac) promotes the expression of spir, providing a specific mechanism linking oocyte polarization to histone modification. |*Gene Expression Regulation, Developmental [MESH] |Acetylation [MESH] |Animals [MESH] |Chromatin Immunoprecipitation [MESH] |Drosophila Proteins/*genetics/*metabolism [MESH] |Drosophila melanogaster/*cytology/*enzymology/genetics [MESH] |Embryo, Nonmammalian [MESH] |Female [MESH] |Histone Acetyltransferases/genetics/*metabolism [MESH] |Histones/metabolism [MESH] |Microfilament Proteins/*genetics/metabolism [MESH] |Mutation [MESH] |Oocytes/cytology/enzymology [MESH] |Ovary/metabolism [MESH]Histone acetyltransferase Enok regulates oocyte polarization by promot(epmc).pdf DeepDyve Pubget Overpricing