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10.1101/gad.252478.114 http://scihub22266oqcxt.onion/10.1101/gad.252478.114 C4265673!4265673!25512557     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+Dev 2014 ; 28 (24): 2693-8 Nephropedia Template TP {{tp|p=25512557|t=2014. PTIP associates with Artemis to dictate DNA repair pathway choice |pdf=|usr=}}{{25512557}} gab.com Text PTIP associates with Artemis to dictate DNA repair pathway choice JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25512557 #FOAvip PARP inhibitors (PARPi) are being used in patients with BRCA1/2 mutations; however, doubly deficient BRCA1?/?53BP1?/? tumors become resistant to PARPis. 53BP1 and its known downstream effectors, PTIP and RIF1, lack enzymatic activities directly implicated in DNA repair. Wang et al. uncovered a nuclease, Artemis, as a PTIP-binding protein that trims DNA ends, promotes NHEJ, and directly competes with the HR repair pathway. Loss of Artemis restores PARPi resistance in BRCA1-deficient cells. Twit Text FOAVip PTIP associates with Artemis to dictate DNA repair pathway choice ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=25512557 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25512557 #FOAvip English Wikipedia <ref>{{Cite pmid|25512557}}</ref> PTIP associates with Artemis to dictate DNA repair pathway choice #MMPMID25512557 Wang J; Aroumougame A; Lobrich M; Li Y; Chen D; Chen J; Gong Z Genes Dev 2014[Dec]; 28 (24): 2693-8 PMID25512557show ga PARP inhibitors (PARPi) are being used in patients with BRCA1/2 mutations; however, doubly deficient BRCA1?/?53BP1?/? tumors become resistant to PARPis. 53BP1 and its known downstream effectors, PTIP and RIF1, lack enzymatic activities directly implicated in DNA repair. Wang et al. uncovered a nuclease, Artemis, as a PTIP-binding protein that trims DNA ends, promotes NHEJ, and directly competes with the HR repair pathway. Loss of Artemis restores PARPi resistance in BRCA1-deficient cells. äPTIP associates with Artemis to dictate DNA repair pathway choice (epmc).pdf DeepDyve Pubget Overpricing