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10.1002/anie.201407061

http://scihub22266oqcxt.onion/10.1002/anie.201407061
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C4265365!4265365!25257803
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suck abstract from ncbi


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pmid25257803      Angew+Chem+Int+Ed+Engl 2014 ; 53 (50): 13746-50
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  • Recognition of Nucleic Acid Junctions Using Triptycene-Based Molecules #MMPMID25257803
  • Barros SA; Chenoweth DM
  • Angew Chem Int Ed Engl 2014[Dec]; 53 (50): 13746-50 PMID25257803show ga
  • Nucleic acid modulation by small molecules is an essential process across the kingdoms of life. Targeting nucleic acids with small molecules represents a significant challenge at the forefront of chemical biology. Nucleic acid junctions are ubiquitous structural motifs in nature and in designed materials. Herein, we describe a new class of structure specific nucleic acid junction stabilizers based on a triptycene scaffold. Triptycenes provide significant stabilization of DNA and RNA three-way junctions, providing a new scaffold for building nucleic acid junction binders with enhanced recognition properties. Additionally, we report cytotoxicity and cell uptake data in two human ovarian carcinoma cell lines.
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