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10.1177/1740774514537727 http://scihub22266oqcxt.onion/10.1177/1740774514537727 C4265005!4265005!24925083     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Trials 2014 ; 11 (4): 408-17 Nephropedia Template TP {{tp|p=24925083|t=2014. Inference about the expected performance of a data-driven dynamic treatment regime |pdf=|usr=}}{{24925083}} gab.com Text Inference about the expected performance of a data-driven dynamic treatment regime JO: Clin Trials http://www.kidney.de/pget.php?&tw=1&pmid=24925083 #FOAvip Background: A dynamic treatment regime (DTR) comprises a sequence of decision rules, one per stage of intervention, that recommends how to individualize treatment to patients based on evolving treatment and covariate history. These regimes are useful for managing chronic disorders, and fit into the larger paradigm of personalized medicine. The Value of a DTR is the expected outcome when the DTR is used to assign treatments to a population of interest. Purpose: The Value of a data-driven DTR, estimated using data from a sequential multiple assignment randomized trial, is both a data-dependent parameter and a non-smooth function of the underlying generative distribution. These features introduce additional variability that is not accounted for by standard methods for conducting statistical inference, e.g., the bootstrap or normal approximations, if applied without adjustment. Our purpose is to provide a feasible method for constructing valid confidence intervals for this quantity of practical interest. Methods: We propose a conceptually simple and computationally feasible method for constructing valid confidence intervals for the Value of an estimated DTR based on subsampling. The method is self-tuning by virtue of an approach called the double bootstrap. We demonstrate the proposed method using a series of simulated experiments. Results: The proposed method offers considerable improvement in terms of coverage rates of the confidence intervals over the standard bootstrap approach. Limitations: In this paper, we have restricted our attention to Q-learning for estimating the optimal DTR. However, other methods can be employed for this purpose; to keep the discussion focused, we have not explored these alternatives. Conclusions: Subsampling-based confidence intervals provide much better performance compared to standard bootstrap for the Value of an estimated DTR. Twit Text FOAVip Inference about the expected performance of a data-driven dynamic treatment regime ????Clin Trials http://www.kidney.de/pget.php?&tw=1&pmid=24925083 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24925083 #FOAvip English Wikipedia <ref>{{Cite pmid|24925083}}</ref> Inference about the expected performance of a data-driven dynamic treatment regime #MMPMID24925083 Chakraborty B; Laber EB; Zhao YQ Clin Trials 2014[Aug]; 11 (4): 408-17 PMID24925083show ga Background: A dynamic treatment regime (DTR) comprises a sequence of decision rules, one per stage of intervention, that recommends how to individualize treatment to patients based on evolving treatment and covariate history. These regimes are useful for managing chronic disorders, and fit into the larger paradigm of personalized medicine. The Value of a DTR is the expected outcome when the DTR is used to assign treatments to a population of interest. Purpose: The Value of a data-driven DTR, estimated using data from a sequential multiple assignment randomized trial, is both a data-dependent parameter and a non-smooth function of the underlying generative distribution. These features introduce additional variability that is not accounted for by standard methods for conducting statistical inference, e.g., the bootstrap or normal approximations, if applied without adjustment. Our purpose is to provide a feasible method for constructing valid confidence intervals for this quantity of practical interest. Methods: We propose a conceptually simple and computationally feasible method for constructing valid confidence intervals for the Value of an estimated DTR based on subsampling. The method is self-tuning by virtue of an approach called the double bootstrap. We demonstrate the proposed method using a series of simulated experiments. Results: The proposed method offers considerable improvement in terms of coverage rates of the confidence intervals over the standard bootstrap approach. Limitations: In this paper, we have restricted our attention to Q-learning for estimating the optimal DTR. However, other methods can be employed for this purpose; to keep the discussion focused, we have not explored these alternatives. Conclusions: Subsampling-based confidence intervals provide much better performance compared to standard bootstrap for the Value of an estimated DTR. äInference about the expected performance of a data-driven dynamic trea(epmc).pdf DeepDyve Pubget Overpricing