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10.15252/embr.201438942

http://scihub22266oqcxt.onion/10.15252/embr.201438942
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C4264932!4264932!25378482
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suck abstract from ncbi


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pmid25378482      EMBO+Rep 2014 ; 15 (12): 1297-304
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  • Epithelial?stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues #MMPMID25378482
  • Obata Y; Kimura S; Nakato G; Iizuka K; Miyagawa Y; Nakamura Y; Furusawa Y; Sugiyama M; Suzuki K; Ebisawa M; Fujimura Y; Yoshida H; Iwanaga T; Hase K; Ohno H
  • EMBO Rep 2014[Dec]; 15 (12): 1297-304 PMID25378482show ga
  • Intrinsic Notch signaling in intestinal epithelial cells restricts secretory cell differentiation. In gut-associated lymphoid tissue (GALT), stromal cells located beneath the follicle-associated epithelium (FAE) abundantly express the Notch ligand delta-like 1 (Dll1). Here, we show that mice lacking Rbpj?a gene encoding a transcription factor implicated in Notch signaling?in intestinal epithelial cells have defective GALT maturation. This defect can be attributed to the expansion of goblet cells, which leads to the down-regulation of CCL20 in FAE. These data demonstrate that epithelial Notch signaling maintained by stromal cells contributes to the full maturation of GALT by restricting secretory cell differentiation in FAE.Subject Categories Development & Differentiation; Immunology; Signal Transduction
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