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10.15252/embr.201438942 http://scihub22266oqcxt.onion/10.15252/embr.201438942 C4264932!4264932 !25378482     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25378482 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+Rep 2014 ; 15 (12 ): 1297-304 Nephropedia Template TP {{tp|p=25378482 |t=2014. Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues |pdf=|usr=}}{{25378482 }} gab.com Text Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25378482 #FOAvip Intrinsic Notch signaling in intestinal epithelial cells restricts secretory cell differentiation. In gut-associated lymphoid tissue (GALT), stromal cells located beneath the follicle-associated epithelium (FAE) abundantly express the Notch ligand delta-like 1 (Dll1). Here, we show that mice lacking Rbpj-a gene encoding a transcription factor implicated in Notch signaling-in intestinal epithelial cells have defective GALT maturation. This defect can be attributed to the expansion of goblet cells, which leads to the down-regulation of CCL20 in FAE. These data demonstrate that epithelial Notch signaling maintained by stromal cells contributes to the full maturation of GALT by restricting secretory cell differentiation in FAE. Twit Text FOAVip Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25378482 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25378482 #FOAvip English Wikipedia <ref>{{Cite pmid|25378482 }}</ref> Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues #MMPMID25378482 Obata Y ; Kimura S ; Nakato G ; Iizuka K ; Miyagawa Y ; Nakamura Y ; Furusawa Y ; Sugiyama M ; Suzuki K ; Ebisawa M ; Fujimura Y ; Yoshida H ; Iwanaga T ; Hase K ; Ohno H EMBO Rep 2014[Dec]; 15 (12 ): 1297-304 PMID25378482 show ga Intrinsic Notch signaling in intestinal epithelial cells restricts secretory cell differentiation. In gut-associated lymphoid tissue (GALT), stromal cells located beneath the follicle-associated epithelium (FAE) abundantly express the Notch ligand delta-like 1 (Dll1). Here, we show that mice lacking Rbpj-a gene encoding a transcription factor implicated in Notch signaling-in intestinal epithelial cells have defective GALT maturation. This defect can be attributed to the expansion of goblet cells, which leads to the down-regulation of CCL20 in FAE. These data demonstrate that epithelial Notch signaling maintained by stromal cells contributes to the full maturation of GALT by restricting secretory cell differentiation in FAE. |Animals [MESH] |Cell Differentiation/physiology [MESH] |Epithelial Cells/*cytology/*metabolism [MESH] |In Vitro Techniques [MESH] |Intestinal Mucosa/cytology/metabolism [MESH] |Lymphoid Tissue/*cytology/*metabolism [MESH] |Mice [MESH] |Receptors, Notch/*metabolism [MESH] |Signal Transduction/physiology [MESH]Epithelial-stromal interaction via Notch signaling is essential for th(epmc).pdf DeepDyve Pubget Overpricing